Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation

被引：11
|
作者：
Tahvildari, Maryam [1 ,2 ]
Amouzegar, Afsaneh [1 ]
Foulsham, William [1 ]
Dana, Reza [1 ]
机构：
[1] Harvard Med Sch, Schepens Eye Res Inst, Massachusetts Eye & Ear Infirm, Boston, MA 02115 USA
[2] Wayne State Univ, Kresge Eye Inst, Detroit, MI USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2018年 / 75卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Corneal transplantation; Graft rejection; Allotolerance; Regulatory T cells; Antigen presenting cells; Corneal hemangiogenesis; Corneal lymphangiogenesis; REGULATORY T-CELLS; ENDOTHELIAL GROWTH-FACTOR; TOLEROGENIC DENDRITIC CELLS; MESENCHYMAL STEM-CELLS; ANTI-CD4; MONOCLONAL-ANTIBODY; GRAFT-SURVIVAL; ALLOGRAFT-REJECTION; IN-VIVO; TRANSPLANT SURVIVAL; FACTOR-C;
D O I：
10.1007/s00018-017-2739-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the cellular and molecular pathways that mediate rejection has deepened, a number of novel therapeutic strategies have been unveiled. This manuscript reviews therapeutic approaches to promote corneal transplant survival through targeting (1) corneal lymphangiogenesis and hemangiogenesis, (2) antigen presenting cells, (3) effector and regulatory T cells, and (4) mesenchymal stem cells.
引用
收藏
页码：1509 / 1520
页数：12
相关论文
共 50 条
  • [1] Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation
    Maryam Tahvildari
    Afsaneh Amouzegar
    William Foulsham
    Reza Dana
    Cellular and Molecular Life Sciences, 2018, 75 : 1509 - 1520
  • [2] Induction of immune tolerance with heart-thymus composite allotransplantation in rats
    Hai-bo Xiong
    Sui-sheng Xia
    Hao Wen
    Zu-fa Huang
    Qi-fa Ye
    Journal of Central South University of Technology, 2005, 12 : 331 - 336
  • [3] Induction of immune tolerance with heart-thymus composite allotransplantation in rats
    Xiong, HB
    Xia, SS
    Wen, H
    Huang, ZF
    Ye, QF
    JOURNAL OF CENTRAL SOUTH UNIVERSITY OF TECHNOLOGY, 2005, 12 (Suppl 1): : 331 - 336
  • [4] Novel peptide therapeutic approaches for immune tolerance
    Allen, SD
    Bernert, H
    Rawale, SV
    VanBuskirk, AM
    Kaumaya, PTP
    BIOPOLYMERS, 2003, 71 (03) : 401 - 401
  • [5] Novel peptide therapeutic approaches for immune tolerance
    Allen, Stephanie D.
    Bernert, Heike
    Rawale, Sharad V.
    VanBuskirk, Anne M.
    Kaumaya, Pravin T. P.
    PEPTIDE REVOLUTION: GENOMICS, PROTEOMICS & THERAPEUTICS, 2004, : 760 - 761
  • [6] Effect of severing corneal nerves on the induction of immune tolerance during corneal transplantation
    Mo, Juan
    Mellon, Jessamee
    Niederkorn, Jerry Y.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
  • [7] Emerging approaches to induce immune tolerance to therapeutic proteins
    Noel, Justine C.
    Lagasse, Daniel
    Golding, Basil
    Sauna, Zuben E.
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2023, 44 (12) : 1028 - 1042
  • [8] Therapeutic induction of antigen-specific immune tolerance
    Kenison, Jessica E.
    Stevens, Nikolas A.
    Quintana, Francisco J.
    NATURE REVIEWS IMMUNOLOGY, 2024, 24 (05) : 338 - 357
  • [9] Therapeutic induction of antigen-specific immune tolerance
    Jessica E. Kenison
    Nikolas A. Stevens
    Francisco J. Quintana
    Nature Reviews Immunology, 2024, 24 : 338 - 357
  • [10] Induction of Immune Tolerance to a Therapeutic Protein by Intrathymic Gene Delivery
    Chu, Qiuming
    Moreland, Rodney J.
    Gao, Lan
    Taylor, Kristin M.
    Meyers, Elizabeth
    Cheng, Seng H.
    Scheule, Ronald K.
    MOLECULAR THERAPY, 2010, 18 (12) : 2146 - 2154
12345