Induction of immune tolerance with heart-thymus composite allotransplantation in rats

被引：0
|
作者：
Xiong, HB [1 ]
Xia, SS
Wen, H
Huang, ZF
Ye, QF
机构：
[1] Cent S Univ, Xiangya Hosp 3, Med Acad Transplantat, Changsha 410013, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Transplantat, Wuhan 430030, Peoples R China
[3] Xinjiang Med Univ, Affiliated Hosp 1, Dept Gen Surg, Urumqi 830054, Peoples R China
来源：
JOURNAL OF CENTRAL SOUTH UNIVERSITY OF TECHNOLOGY | 2005年 / 12卷 / Suppl 1期
关键词：
thymus; transplantation; immune tolerance; rejection; rat;
D O I：
10.1007/s11771-005-0424-z
中图分类号：
TF [冶金工业];
学科分类号：
0806 ;
摘要：
Objective To study on the role of thymus transplantation for heart allograft in rats. Methods Vascularized heart-thymus combined transplantation was performed with microsurgical technique. Graft survival, histopathology, level of IL-2, IL-4 and its mRNA expression in serum and cardiac grafts were investigated. Results Heart-thymus combined transplantation achieved effect in the prolongation of cardiac graft survival with short-term administration of cyclosporine. Conclusions Vascularized thymus transplantation induced immune tolerance in thymectomized rats.
引用
收藏
页码：331 / 336
页数：6
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