Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation

被引：11

作者：

Tahvildari, Maryam ^{[1
,2
]}

Amouzegar, Afsaneh ^{[1
]}

Foulsham, William ^{[1
]}

Dana, Reza ^{[1
]}

机构：

[1] Harvard Med Sch, Schepens Eye Res Inst, Massachusetts Eye & Ear Infirm, Boston, MA 02115 USA

[2] Wayne State Univ, Kresge Eye Inst, Detroit, MI USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2018年 / 75卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Corneal transplantation; Graft rejection; Allotolerance; Regulatory T cells; Antigen presenting cells; Corneal hemangiogenesis; Corneal lymphangiogenesis; REGULATORY T-CELLS; ENDOTHELIAL GROWTH-FACTOR; TOLEROGENIC DENDRITIC CELLS; MESENCHYMAL STEM-CELLS; ANTI-CD4; MONOCLONAL-ANTIBODY; GRAFT-SURVIVAL; ALLOGRAFT-REJECTION; IN-VIVO; TRANSPLANT SURVIVAL; FACTOR-C;

D O I：

10.1007/s00018-017-2739-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cornea is the most commonly transplanted tissue in the body. Corneal grafts in low-risk recipients enjoy high success rates, yet over 50% of high-risk grafts (with inflamed and vascularized host beds) are rejected. As our understanding of the cellular and molecular pathways that mediate rejection has deepened, a number of novel therapeutic strategies have been unveiled. This manuscript reviews therapeutic approaches to promote corneal transplant survival through targeting (1) corneal lymphangiogenesis and hemangiogenesis, (2) antigen presenting cells, (3) effector and regulatory T cells, and (4) mesenchymal stem cells.

引用

页码：1509 / 1520

页数：12

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