Bacterial proteases: targets for diagnostics and therapy

被引：30
|
作者：
Kaman, W. E. [1 ,2 ,3 ]
Hays, J. P. [1 ]
Endtz, H. P. [1 ]
Bikker, F. J. [2 ,3 ]
机构：
[1] Erasmus MC, Dept Med Microbiol & Infect Dis, NL-3015 CE Rotterdam, Netherlands
[2] Univ Amsterdam, Acad Ctr Dent Amsterdam, Dept Oral Biochem, NL-1081 LA Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, NL-1081 LA Amsterdam, Netherlands
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2014年 / 33卷 / 07期
关键词：
ANTHRAX LETHAL FACTOR; PORPHYROMONAS-GINGIVALIS; CYSTEINE PROTEINASES; SUBSTRATE-SPECIFICITY; PROTEOLYTIC-ENZYMES; BACILLUS-SUBTILIS; PEPTIDE LIBRARY; INHIBITORS; IDENTIFICATION; PENICILLIN;
D O I：
10.1007/s10096-014-2075-1
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Proteases are essential for the proliferation and growth of bacteria, and are also known to contribute to bacterial virulence. This makes them interesting candidates as diagnostic and therapeutic targets for infectious diseases. In this review, the authors discuss the most recent developments and potential applications for bacterial proteases in the diagnosis and treatment of bacterial infections. Current and future bacterial protease targets are described and their limitations outlined.
引用
收藏
页码：1081 / 1087
页数：7
相关论文
共 50 条
  • [1] Bacterial proteases: targets for diagnostics and therapy
    W. E. Kaman
    J. P. Hays
    H. P. Endtz
    F. J. Bikker
    European Journal of Clinical Microbiology & Infectious Diseases, 2014, 33 : 1081 - 1087
  • [2] Bacterial proteases, untapped antimicrobial drug targets
    Elizabeth Culp
    Gerard D Wright
    The Journal of Antibiotics, 2017, 70 : 366 - 377
  • [3] Bacterial proteases, untapped antimicrobial drug targets
    Culp, Elizabeth
    Wright, Gerard D.
    JOURNAL OF ANTIBIOTICS, 2017, 70 (04): : 366 - 377
  • [4] Serine proteases as targets for antithrombotic therapy
    Ries, UJ
    Wienen, W
    DRUGS OF THE FUTURE, 2003, 28 (04) : 355 - 370
  • [5] Bacterial caseinolytic proteases as novel targets for antibacterial treatment
    Broetz-Oesterhelt, Heike
    Sass, Peter
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2014, 304 (01) : 23 - 30
  • [6] SUMO proteases as potential targets for cancer therapy
    Bialik, Piotr
    Wozniak, Katarzyna
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2017, 71 : 997 - 1004
  • [7] SENP Proteases as Potential Targets for Cancer Therapy
    Tokarz, Paulina
    Wozniak, Katarzyna
    CANCERS, 2021, 13 (09)
  • [8] Transmembrane proteases as disease markers and targets for therapy
    Antczak, C
    De Meester, I
    Bauvois, B
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2001, 15 (02): : 130 - 139
  • [9] Bacterial Skin Infections - Diagnostics and Therapy
    Roethig, Anja
    TIERAERZTLICHE UMSCHAU, 2022, 77 (03) : 54 - 59
  • [10] Bacterial sepsis: Diagnostics and calculated antibiotic therapy
    Richter, D. C.
    Heininger, A.
    Brenner, T.
    Hochreiter, M.
    Bernhard, M.
    Briegel, J.
    Dubler, S.
    Grabein, B.
    Hecker, A.
    Kruger, W. A.
    Mayer, K.
    Pletz, M. W.
    Storzinger, D.
    Pinder, N.
    Hoppe-Tichy, T.
    Weiterer, S.
    Zimmermann, S.
    Brinkmann, A.
    Weigand, M. A.
    Lichtenstern, C.
    ANAESTHESIST, 2019, 68 : 40 - 62
12345