Bacterial proteases: targets for diagnostics and therapy

被引：30

作者：

Kaman, W. E. ^{[1
,2
,3
]}

Hays, J. P. ^{[1
]}

Endtz, H. P. ^{[1
]}

Bikker, F. J. ^{[2
,3
]}

机构：

[1] Erasmus MC, Dept Med Microbiol & Infect Dis, NL-3015 CE Rotterdam, Netherlands

[2] Univ Amsterdam, Acad Ctr Dent Amsterdam, Dept Oral Biochem, NL-1081 LA Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, NL-1081 LA Amsterdam, Netherlands

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2014年 / 33卷 / 07期

关键词：

ANTHRAX LETHAL FACTOR; PORPHYROMONAS-GINGIVALIS; CYSTEINE PROTEINASES; SUBSTRATE-SPECIFICITY; PROTEOLYTIC-ENZYMES; BACILLUS-SUBTILIS; PEPTIDE LIBRARY; INHIBITORS; IDENTIFICATION; PENICILLIN;

D O I：

10.1007/s10096-014-2075-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Proteases are essential for the proliferation and growth of bacteria, and are also known to contribute to bacterial virulence. This makes them interesting candidates as diagnostic and therapeutic targets for infectious diseases. In this review, the authors discuss the most recent developments and potential applications for bacterial proteases in the diagnosis and treatment of bacterial infections. Current and future bacterial protease targets are described and their limitations outlined.

引用

页码：1081 / 1087

页数：7

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