SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL IMIDAZOLINONE DERIVATIVES CARRYING BENZIMIDAZOLE

被引：0

作者：

Revanasiddappa, B. C. ^{[1
]}

Kalsi, Jasmine ^{[1
]}

Jisha, M. S. ^{[1
]}

Varghese, Saira Susan ^{[1
]}

Jose, Neethu ^{[1
]}

机构：

[1] Nitte Univ, NGSM Inst Pharmaceut Sci, Dept Pharmaceut Chem, Deralakatte 575018, Mangalore, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 25卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of oxazolones (2a-j) was prepared by reacting substituted aromatic aldehydes with N-acetylglycine in presence of anhydrous sodium acetate and acetic anhydride as the solvent medium. The respective oxazolones (2a-j) were treated with 2-aminobenzothiazole (1) in glacial acetic acid medium to yield the title compounds imidazolinone derivatives (3a-j). All the newly synthesized compounds were evaluated for their in-vitro antibacterial and antifungal activities. The structures of new compounds were assigned on the basis of H-1 NMR, IR, Mass spectral data and elemental analysis. Some of the tested compounds showed good activity against A. fumigatus.

引用

页码：1 / 4

页数：4

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