SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL N-MANNICH BASES OF BENZIMIDAZOLE DERIVATIVES

被引：0
|
作者：
Sugumaran, Murugesan [1 ]
Rajasekhar, Sreerama [1 ]
机构：
[1] Adhiparasakthi Coll Pharm, Dept Pharmaceut Chem, Melmaruvathur 600319, Tamil Nadu, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 22卷 / 01期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel series of benzimidazole derivatives was synthesized. The reaction of N-1 hydrogen of 2- substituted benzimidazoles (SR1-3) with primary (sulphanilamide) and or secondary (piperazine) amines in ethanol yielded the corresponding N-Mannich bases (SR4-9). The structures of synthesized compounds were elucidated by UV, IR, H-1 NMR and mass spectral analysis. Final compounds were evaluated for their antimicrobial activity by disc diffusion method. All the synthesized derivatives exhibited very good antibacterial and antifungal activities.
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页码：31 / 34
页数：4
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