Lanostane-type C31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris

被引：14
|
作者：
Zhao, Jinzhi [1 ,2 ]
Yang, Yun [1 ]
Yu, Mengyao [3 ]
Yao, Ke [3 ]
Luo, Xia [3 ]
Qi, Huayi [1 ]
Zhang, Guolin [1 ]
Luo, Yinggang [1 ]
机构：
[1] Chinese Acad Sci, Chengdu Inst Biol, 9 Sect 4,Renmin Rd South, Chengdu 610041, Sichuan, Peoples R China
[2] Univ Chinese Acad Sci, 19A Yuguan Rd, Beijing 100049, Peoples R China
[3] Sichuan Acad Chinese Med Sci, Inst Med Fungi, 51 Sect 4,Renmin Rd South, Chengdu 610041, Sichuan, Peoples R China
来源：
PHYTOCHEMISTRY | 2018年 / 152卷
关键词：
Fomitopsis palustris; Fomitopsidaceae; Lanostane; Triterpenoid; Palustrisoic acid; Palustrisolide; Cytotoxicity; PIPTOPORUS-BETULINUS; CYCLOLANOSTANOL XYLOSIDE; BEESIA-CALTHAEFOLIA; SOULIEA-VAGINATA; PORIA-COCOS; FUNGUS; CONSTITUENTS; PINICOLA; LACTONES; STEREOCHEMISTRY;
D O I：
10.1016/j.phytochem.2018.04.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fifteen undescribed and five known lanostane-type C-31 triterpenoid derivatives were isolated from the aqueous EtOH extract of the fruiting bodies of cultivated Fomitopsis palustris. Their structures were identified from the spectroscopic data and chemical degradation studies. The structures of palustrisoic acids A and H were confirmed by X-ray crystallography. Polyporenic acid B showed strong cytotoxicity against the HCT116, A549, and HepG2 cell lines with IC50 values of 8.4, 12.1, and 12.2 mu M, respectively. Palustrisolides A, C, and G displayed weak cytotoxicity. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：10 / 21
页数：12
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