Eosinophilic esophagitis

被引：26

作者：

Merves, Jamie ^{[1
,2
]}

Muir, Amanda ^{[1
,2
]}

Chandramouleeswaran, Prasanna Modayur ^{[1
,2
]}

Cianferoni, Antonella ^{[2
,3
]}

Wang, Mei-Lun ^{[1
,2
]}

Spergel, Jonathan M. ^{[2
,3
]}

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Div Gastroenterol & Nutr, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Childrens Hosp Philadelphia, Div Allergy & Immunol, Philadelphia, PA 19104 USA

来源：

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | 2014年 / 112卷 / 05期

关键词：

THYMIC STROMAL LYMPHOPOIETIN; FLUTICASONE PROPIONATE; PEDIATRIC-PATIENTS; ELIMINATION DIET; GENE-EXPRESSION; DOUBLE-BLIND; MOUSE MODEL; MAST-CELL; T-CELLS; CHILDREN;

D O I：

10.1016/j.anai.2014.01.023

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Objective: To review the understanding of the pathogenesis of eosinophilic esophagitis ( EoE) and the role of the immune system in the disease process. Data Sources: Peer-reviewed articles on EoE from PubMed searching for "Eosinophilic Esophagitis and fibrosis" in the period of 1995 to 2013. Study Selections: Studies on the clinical and immunologic features, pathogenesis, and management of EoE. Results: Recent work has revealed that thymic stromal lymphopoietin and basophil have an increased role in the pathogenesis of disease. Additional understanding on the role of fibrosis in EoE is emerging. Conclusion: The incidence of EoE is increasing like most atopic disease. Similar to other allergic diseases, EoE is treated with topical steroids and/or allergen avoidance. (C) 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

引用

页码：397 / 403

页数：7

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