Characterization of the activity of L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt in hydroxyl radical elimination

被引：0

作者：

Tomita, T ^{[1
]}

Kashima, M ^{[1
]}

Tsujimoto, Y ^{[1
]}

机构：

[1] Nihon Univ, Sch Dent, Dept Endodont, Chiba 2718587, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2000年 / 48卷 / 03期

关键词：

ESR; hydroxyl radical; scavenging; L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-( 4,8,12- trimethyltridecyl)-2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt (EPC-K-1) on hydroxyl radical(. OH) elimination was studied using electron spin resonance (ESR) and spectrophotometric experiments. The addition of EFC-K-t and . OH scavengers eliminated the . OH generated from Cu2+/H2O2, Fe2+/H2O2 and H2O2/UV-irradiation reaction systems. However, in competitive reactions using different concentrations of a spin-trap agent, the addition of the . OH scavenger altered the IC50 values, whereas the addition of EPC-K-1 and a metal chelater did not change the value in the Cu2+/H2O2 and Fe2+/H2O2 reaction systems. The addition of EPC-K-1 and metal chelater changed the ESR signal for free Cu2+. The spectrophotometric experiments confirmed that the addition of EPC-K-1 and metal chelater altered the absorption spectra due to CuCl2 and FeSO4, whereas the . OH scavenger did nut alter the spectra. Therefore, it was demonstrated that EPC-K-1 has the ability both to scavenge . OH directly and to inhibit the generation of . OH by the chelation of Cu2+ and Fe2+.

引用

页码：330 / 333

页数：4

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