Revealing the Inter-Module Interactions of Multi-Modular Nonribosomal Peptide Synthetases

被引：5
|
作者：
Lott, J. Shaun [1 ]
Lee, T. Verne [1 ]
机构：
[1] Univ Auckland, Sch Biol Sci, Auckland 1142, New Zealand
来源：
STRUCTURE | 2017年 / 25卷 / 05期
关键词：
BIOSYNTHESIS; PROTEIN; CARRIER;
D O I：
10.1016/j.str.2017.04.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nonribosomal peptide synthetase (NRPS) enzymes are large modular proteins involved in the biosynthesis of many important pharmaceuticals such as penicillin and cyclosporin. In this issue of Structure, Tarry et al. (2017) use X-ray crystallography and electron microscopy to shed light on the inter-module interactions that underpin the complex function of these enzymes.
引用
收藏
页码：693 / 695
页数：3
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