Probing Fleeting Interactions in Large and Dynamic Nonribosomal Peptide Synthetases with Novel NMR Methods

被引：0
|
作者：
Frueh, Dominique P. [1 ]
Goodrich, Andrew C. [1 ]
Harden, Bradley J. [1 ]
Nichols, Scott R. [1 ]
Mishra, Subrata H. [1 ]
机构：
[1] Johns Hopkins Sch Med, Biophys & Biophys Chem, Baltimore, MD USA
来源：
BIOPHYSICAL JOURNAL | 2015年 / 108卷 / 02期
关键词：
D O I：
10.1016/j.bpj.2014.11.352
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
292-Pos
引用
收藏
页码：58A / 58A
页数：1
相关论文
共 26 条
  • [1] Probing the protein-protein interactions in nonribosomal peptide synthetases: Understanding the mechanism of epimerization domain activity
    Kim, Woojoo
    Patel, Ashay
    Burkart, Michael
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [2] Probing the protein-protein interactions in nonribosomal peptide synthetases: Understanding the mechanism of epimerization domain activity
    Kim, Woojoo
    Patel, Ashay
    Burkart, Michael
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [3] Probing Exchange Units for Combining Iterative and Linear Fungal Nonribosomal Peptide Synthetases
    Steiniger, Charlotte
    Hoffmann, Sylvester
    Suessmuth, Roderich D.
    CELL CHEMICAL BIOLOGY, 2019, 26 (11): : 1526 - +
  • [4] Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases
    Liu, Ye
    Zheng, Tengfei
    Bruner, Steven D.
    CHEMISTRY & BIOLOGY, 2011, 18 (11): : 1482 - 1488
  • [5] Revealing the Inter-Module Interactions of Multi-Modular Nonribosomal Peptide Synthetases
    Lott, J. Shaun
    Lee, T. Verne
    STRUCTURE, 2017, 25 (05) : 693 - 695
  • [6] Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics
    Eppelmann, K
    Stachelhaus, T
    Marahiel, MA
    BIOCHEMISTRY, 2002, 41 (30) : 9718 - 9726
  • [7] Probing and Engineering the Fatty Acyl Substrate Selectivity of Starter Condensation Domains of Nonribosomal Peptide Synthetases in Lipopeptide Biosynthesis
    Liu, Qian
    Fan, Wenjie
    Zhao, Yajin
    Deng, Zixin
    Feng, Yan
    BIOTECHNOLOGY JOURNAL, 2020, 15 (02)
  • [8] Modular catalytic activity of nonribosomal peptide synthetases depends on the dynamic interaction between adenylation and condensation domains
    Peng, Ye-Jun
    Chen, Yuxing
    Zhou, Cong-Zhao
    Miao, Wei
    Jiang, Yong-Liang
    Zeng, Xiaoli
    Zhang, Cheng-Cai
    STRUCTURE, 2024, 32 (04) : 440 - 452.e4
  • [9] Exploring the Adenylation Domain Repertoire of Nonribosomal Peptide Synthetases Using an Ensemble of Sequence-Search Methods
    Agueero-Chapin, Guillermin
    Molina-Ruiz, Reinaldo
    Maldonado, Emanuel
    de la Riva, Gustavo
    Sanchez-Rodriguez, Aminael
    Vasconcelos, Vitor
    Antunes, Agostinho
    PLOS ONE, 2013, 8 (07):
  • [10] Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry
    Dorrestein, PC
    Blackhall, J
    Straight, PD
    Fischbach, MA
    Garneau-Tsodikova, S
    Edwards, DJ
    McLaughlin, S
    Lin, M
    Gerwick, WH
    Kolter, R
    Walsh, CT
    Kelleher, NL
    BIOCHEMISTRY, 2006, 45 (06) : 1537 - 1546
123