Synthesis of some novel 3-methyl-6-(2-substituted propanoyl/propyl)-2-benzoxazolinone derivatives and anti-nociceptive activity

被引：8
|
作者：
Çalis, Ü [1 ]
Gökhan, N [1 ]
Erdogan, H [1 ]
机构：
[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
来源：
FARMACO | 2001年 / 56卷 / 09期
关键词：
2-benzoxazolinone; acylation; reduction; anti-nociceptive activity;
D O I：
10.1016/S0014-827X(01)01132-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study, 12 new 3-methyl-6-(2-substituted aminopropanoyl)-2-benzoxazolinone and 3-methyl-6-(1-hydroxy-2-substituted aminopropyl)-2-benzoxazolinone derivatives have been prepared. Their structures have been elucidated by IR, H-1 NMR spectra and by elementary analysis. The anti-nociceptive activity of these compounds has been investigated by using a modified Koster test. It was found that most compounds are capable of inducing anti-nociception in animals. (C) 2001 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：719 / 724
页数：6
相关论文
共 50 条
  • [41] SYNTHESIS AND CHEMISTRY OF 2-METHYL-2-BENZOYL-3-PHENYLAZIRIDINE AND SOME 1-SUBSTITUTED DERIVATIVES
    NAGEL, DL
    CROMWELL, NH
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1974, 11 (06) : 1093 - 1096
  • [42] SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF SOME NOVEL 2-AMINOBENZOTHIAZOLE DERIVATIVES
    Kumar, Arun
    Shakya, Ashok K.
    Siddiqui, H. H.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 25 (3-4) : 243 - 249
  • [43] Synthesis of some new 2-substituted benzoxazol-5-carbonyl3,5-dimethyl pyrazole and 2-substituted benzoxazol-5-carbonyl-3-methyl pyrazalones
    Jyothi, M.
    Satyanarayana, N.
    Sarangapani
    ORIENTAL JOURNAL OF CHEMISTRY, 2009, 25 (03) : 743 - 745
  • [44] Synthesis and Anticancer Activity of Some 2-[3/4-(2-Substituted Phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one Derivatives
    Gundogdu-Karaburun, Nalan
    Karaburun, Ahmet Cagri
    Demirayak, Seref
    Kayagil, Ismail
    Yurttas, Leyla
    LETTERS IN DRUG DESIGN & DISCOVERY, 2014, 11 (05) : 578 - 585
  • [45] Utilization of 2-substituted 3, 1-benzoxazin-4-ones in synthesis of some quinazoline annulated derivatives
    Abd-Alaziz, Asmaa M.
    Sallam, Hanan A.
    Youssef, Ahmed S. A.
    El-Naggar, Abeer M.
    SYNTHETIC COMMUNICATIONS, 2020, 50 (06) : 879 - 892
  • [46] Synthesis of some novel ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2H-pyrano [2, 3-b] pyridine-3-carboxylate derivatives
    Kumar, N. Vasanth
    Mashelker, Uday C.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2006, 45 (07): : 1770 - 1773
  • [47] Pyrimidine-5-carbonitriles - part III: synthesis and antimicrobial activity of novel 6-(2-substituted propyl)-2,4-disubstituted pyrimidine-5-carbonitriles
    Al-Deeb, Omar A.
    Al-Turkistani, Abdulghafoor A.
    Al-Abdullah, Ebtehal S.
    El-Brollosy, Nasser R.
    Habib, Elsayed E.
    El-Emam, Ali A.
    HETEROCYCLIC COMMUNICATIONS, 2013, 19 (06) : 411 - 419
  • [48] Synthesis and activity mechanism of some novel 2-substituted benzothiazoles as hGSTP1-1 enzyme inhibitors
    Bolelli, K.
    Musdal, Y.
    Aki-Yalcin, E.
    Mannervik, B.
    Yalcin, I.
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2017, 28 (11) : 927 - 940
  • [49] Synthesis, Anti-Inflammatory and Anti-Nociceptive Activities and Cytotoxic Effect of Novel Thiazolidin-4-ones Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors
    Moallem, Seyed Adel
    Imenshahidi, Mohsen
    Shahini, Narges
    Javan, Ahmad Reza
    Karimi, Mohsen
    Alibolandi, Mona
    Ghandadi, Morteza
    Etemad, Leila
    Motamedshariaty, Vahidehsadat
    Hosseini, Toktam
    Hadizadeh, Farzin
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2013, 16 (12) : 1238 - 1244
  • [50] Synthesis and Herbicidal Activity of 2-Substituted Amino-5-dehydroabietyl-1,3,4-oxadiazole Derivatives
    Mo, Qijin
    Duan, Wengui
    Li, Xingren
    Huang, Danping
    Luo, Zhanjiang
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2011, 31 (07) : 1114 - 1121
12345