Synthesis of some novel 3-methyl-6-(2-substituted propanoyl/propyl)-2-benzoxazolinone derivatives and anti-nociceptive activity

被引：8

作者：

Çalis, Ü ^{[1
]}

Gökhan, N ^{[1
]}

Erdogan, H ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

来源：

FARMACO | 2001年 / 56卷 / 09期

关键词：

2-benzoxazolinone; acylation; reduction; anti-nociceptive activity;

D O I：

10.1016/S0014-827X(01)01132-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, 12 new 3-methyl-6-(2-substituted aminopropanoyl)-2-benzoxazolinone and 3-methyl-6-(1-hydroxy-2-substituted aminopropyl)-2-benzoxazolinone derivatives have been prepared. Their structures have been elucidated by IR, H-1 NMR spectra and by elementary analysis. The anti-nociceptive activity of these compounds has been investigated by using a modified Koster test. It was found that most compounds are capable of inducing anti-nociception in animals. (C) 2001 Elsevier Science S.A. All rights reserved.

引用

页码：719 / 724

页数：6

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