Synthesis of some novel 3-methyl-6-(2-substituted propanoyl/propyl)-2-benzoxazolinone derivatives and anti-nociceptive activity

被引：8
|
作者：
Çalis, Ü [1 ]
Gökhan, N [1 ]
Erdogan, H [1 ]
机构：
[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
来源：
FARMACO | 2001年 / 56卷 / 09期
关键词：
2-benzoxazolinone; acylation; reduction; anti-nociceptive activity;
D O I：
10.1016/S0014-827X(01)01132-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study, 12 new 3-methyl-6-(2-substituted aminopropanoyl)-2-benzoxazolinone and 3-methyl-6-(1-hydroxy-2-substituted aminopropyl)-2-benzoxazolinone derivatives have been prepared. Their structures have been elucidated by IR, H-1 NMR spectra and by elementary analysis. The anti-nociceptive activity of these compounds has been investigated by using a modified Koster test. It was found that most compounds are capable of inducing anti-nociception in animals. (C) 2001 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：719 / 724
页数：6
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