Pd/C-mediated synthesis of α-pyrone fused with a five-membered nitrogen heteroaryl ring: A new route to pyrano[4,3-c]pyrazol-4(1H)-ones

被引：14
|
作者：
Gorja, Dhilli Rao [2 ]
Batchu, Venkateswara Rao [3 ]
Ettam, Ashok [3 ]
Pal, Manojit [1 ]
机构：
[1] Matrix Labs Ltd, R&D Ctr, New Drug Discovery, Jinnaram Mandal 502325, Andhra Pradesh, India
[2] JNT Univ, Inst Sci & Technol, Hyderabad 500072, Andhra Pradesh, India
[3] Dr Reddys Labs Ltd, Hyderabad 500049, Andhra Pradesh, India
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 5卷
关键词：
C-C bond; catalysis; palladium; pyrazole; pyrone; PALLADIUM-CATALYZED HETEROANNULATION; O-IODOBENZOIC ACID; TERMINAL ALKYNES; ISOCOUMARINS; CYCLIZATION; PHTHALIDES;
D O I：
10.3762/bjoc.5.64
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pd/C-mediated alkynylation of 5-iodo-pyrazole-4-carboxylic acid, involving the first regioselective construction of alpha-pyrone ring on a pyrazol moiety via tandem coupling-cyclization process, has been developed to afford pyrano[4,3-c]pyrazol-4(1H)-one in a single pot.
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页数：5
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