Pd/C-mediated synthesis of α-pyrone fused with a five-membered nitrogen heteroaryl ring: A new route to pyrano[4,3-c]pyrazol-4(1H)-ones

被引：14

作者：

Gorja, Dhilli Rao ^{[2
]}

Batchu, Venkateswara Rao ^{[3
]}

Ettam, Ashok ^{[3
]}

Pal, Manojit ^{[1
]}

机构：

[1] Matrix Labs Ltd, R&D Ctr, New Drug Discovery, Jinnaram Mandal 502325, Andhra Pradesh, India

[2] JNT Univ, Inst Sci & Technol, Hyderabad 500072, Andhra Pradesh, India

[3] Dr Reddys Labs Ltd, Hyderabad 500049, Andhra Pradesh, India

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 5卷

关键词：

C-C bond; catalysis; palladium; pyrazole; pyrone; PALLADIUM-CATALYZED HETEROANNULATION; O-IODOBENZOIC ACID; TERMINAL ALKYNES; ISOCOUMARINS; CYCLIZATION; PHTHALIDES;

D O I：

10.3762/bjoc.5.64

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd/C-mediated alkynylation of 5-iodo-pyrazole-4-carboxylic acid, involving the first regioselective construction of alpha-pyrone ring on a pyrazol moiety via tandem coupling-cyclization process, has been developed to afford pyrano[4,3-c]pyrazol-4(1H)-one in a single pot.

引用

页数：5

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