Formulation design and evaluation of aceclofenac nanogel for topical application

被引：25

作者：

Alam, Md. Shoaib ^{[1
,3
]}

Algahtani, Mohammed S. ^{[2
]}

Ahmad, Javed ^{[2
]}

Kohli, Kanchan ^{[3
]}

Shafiq-un-Nabi, Sheikh ^{[1
]}

Warsi, Musarrat Husain ^{[4
]}

Ahmad, Mohammad Zaki ^{[2
]}

机构：

[1] Jamjoom Pharmaceut, Res & Dev, Jeddah, Saudi Arabia

[2] Najran Univ, Dept Pharmaceut, Coll Pharm, Najran, Saudi Arabia

[3] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi, India

[4] Taif Univ, Coll Pharm, Dept Pharmaceut & Ind Pharm, Taif Al Haweiah, Saudi Arabia

来源：

THERAPEUTIC DELIVERY | 2020年 / 11卷 / 12期

关键词：

aceclofenac; carbopol; 940; high-pressure homogenization; nanoemulsion; nanoemulgel; topical application; HIGH-PRESSURE HOMOGENIZATION; LIFE SETTING TRIALS; DRUG-DELIVERY; IN-VITRO; OSTEOARTHRITIS EVIDENCE; TRANSDERMAL DELIVERY; NANOEMULSION; SYSTEMS; MANAGEMENT; NSAIDS;

D O I：

10.4155/tde-2020-0076

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: The current study aimed to explore the feasibility of the nanoemulgel for the topical delivery of aceclofenac. Materials & methods: Solubility of drugs in the formulation systems was determined and aceclofenac nanoemulsion (NE) was prepared by high-pressure homogenization technique. Carbopol 940 was added as a gelling agent. Results & conclusion: The composition of optimized NE consist of labrafil along with triacetin as oil, tween 80 and cremophor EL in combination as a surfactant and transcutol HP along with PEG 400 and ethanol as cosurfactant. The droplet size of the NE was 141.1 +/- 3.65 nm, with low polydispersity index and negative zeta potential. The aceclofenac-nanoemulgel was developed using carbopol 940 and exhibited excellent permeation in comparison to the marketed sample.

引用

页码：767 / 778

页数：12

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