Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac

被引：0
|
作者：
Lakshmana, Prabu S. [1 ]
Shirwaikar, A. A. [1 ]
Shirwaikar, A. [1 ]
Kumar, A. [1 ]
机构：
[1] Manipal Univ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut Qual Assurance, Manipal 576104, Karnataka, India
来源：
ARS PHARMACEUTICA | 2009年 / 50卷 / 02期
关键词：
Aceclofenac; Rosin; Microspheres; Sustained release;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aceclofenac was microencapsulated using rosin by o/w emulsion solvent evaporation technique. The effect of three formulation variables including the drug: polymer ratio, emulsifier (polyvinyl alcohol) concentration and organic solvent (dichloromethane) volume were examined. The prepared batches were characterized for microspheres particle size distribution, encapsulation efficiency and in vitro release behavior. The study reveals that drug: polymer ratio had a considerable effect on the entrapment efficiency, however particle size distribution of microspheres was more dependent on the volume of dichloromethane and polyvinyl alcohol concentration rather than on the drug: polymer ratio. Drug, polymer concentrations were varied to obtain optimum release profile for sustaining the action of the drug.
引用
收藏
页码：51 / 62
页数：12
相关论文
共 50 条
  • [1] Formulation and in Vitro Evaluation of Once Daily Sustained Release Formulation of Aceclofenac
    Ghosh, Santanu
    Barik, B. B.
    [J]. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2010, 9 (03) : 265 - 273
  • [2] Formulation optimization and evaluation of aceclofenac sustained release dosage form based on Kollidon sustained release
    Panikkarakayil, Habeeb
    Nampoothiri, Madhavan
    Kachappilly, Gladis
    Shameem, Mohammed
    Pariyani, Raghunath
    Anitha, Y.
    [J]. ASIAN JOURNAL OF PHARMACEUTICS, 2013, 7 (01) : 8 - 14
  • [3] FORMULATION AND EVALUATION OF SUSTAINED RELEASE AMBROXOL HYDROCHLORIDE MICROSPHERES
    Dhot, Rupinder
    Singh, Karambir
    Shaheeda
    Shabbeer, Shaik
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2012, 3 (05): : 1466 - 1474
  • [4] FORMULATION DESIGN AND EVALUATION OF SAXAGLIPTIN SUSTAINED RELEASE MICROSPHERES
    Naresh, N. S.
    Pratyusha, A.
    [J]. INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 3 (06): : 627 - 636
  • [5] Sustained release sodium alginate microspheres formulation of aceclofenac and paracetamol as potential combination therapy in arthritis
    Jamil, S.
    Kohli, K.
    Khar, F. K.
    Talegaonker, S.
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2007, 59 : A43 - A44
  • [6] FORMULATION AND EVALUATION OF CYCLOBENZAPRINE HYDROCHLORIDE LOADED SUSTAINED RELEASE MICROSPHERES
    Mogili, Rama Kotaiah
    Rao, Koteswara C. H.
    Rao, Prasad M.
    Lakshman, P.
    [J]. INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 1 (04): : 230 - 240
  • [7] Preparation and evaluation of delayed release aceclofenac microspheres
    Radhika, Parasuram Rajam
    Luqman, Moidutty
    Borkhataria, Chetan Hardas
    [J]. ASIAN JOURNAL OF PHARMACEUTICS, 2008, 2 (04) : 252 - 254
  • [8] Chitosan-Montmorillonite Polymer Composites: Formulation and Evaluation of Sustained Release Tablets of Aceclofenac
    Thakur, Garima
    Singh, Amrinder
    Singh, Inderbir
    [J]. SCIENTIA PHARMACEUTICA, 2016, 84 (04) : 603 - 617
  • [9] FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS CONTAINING ANTIOXIDANTS
    Cantoni, J.
    Tous, S. Shawky
    Bataille, B.
    Prinderre, P.
    Reynier, J. P.
    Hansel-Esteller, S.
    [J]. BULLETIN OF PHARMACEUTICAL SCIENCES, 2010, 33 : 9 - 18
  • [10] Formulation and evaluation of sustained release microspheres of poly-lactide-co-glycolide containing tamoxifen citrate
    Sehra, S
    Dhake, AS
    [J]. JOURNAL OF MICROENCAPSULATION, 2005, 22 (05) : 521 - 528
12345