Highly Enantioselective Construction of the α-Chiral Center of Amides via Iridium-Catalyzed Hydrogenation of α,β-Unsaturated Amides

被引：35
|
作者：
Lu, Wei-Jing [1 ]
Hou, Xue-Long [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 09期
基金：
中国国家自然科学基金;
关键词：
amides; enantioselectivity; hydrogenation; iridium; P; N ligands; ASYMMETRIC HECK REACTION; HIV-PROTEASE INHIBITORS; SOLID-PHASE; HETEROAROMATIC-COMPOUNDS; PHOSPHORUS LIGANDS; OLEFINS; QUINOLINES; COMPLEXES; AUXILIARY; PSEUDOEPHEDRINE;
D O I：
10.1002/adsc.200900080
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The chiral center at the cc-position of amides is installed in excellent enantioselectivity via the iridium-catalyzed asymmetric hydrogenation of alpha,beta-unsaturated amides under mild conditions. Even aliphatic amides are suitable substrates. The presence of a hydrogen atom on the nitrogen of the amide is important for the enantioselectivity of the reaction.
引用
收藏
页码：1224 / 1228
页数：5
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