Enantioselective Synthesis of α-Chiral Amides by Catalytic Hydrogenation with Iridium N,P-Complexes

被引：2

作者：

Peters, Bram B. C. ^{[1
]}

Birke, Norman ^{[1
]}

Massaro, Luca ^{[1
]}

Andersson, Pher G. ^{[1
,2
]}

机构：

[1] Stockholm Univ, Dept Organ Chem, Svante Arrhenius vag 16C, S-10691 Stockholm, Sweden

[2] Univ Kwazulu Natal, Sch Chem & Phys, Private Bag X54001, ZA-4000 Durban, South Africa

来源：

SYNLETT | 2023年 / 34卷 / 12期

基金：

瑞典研究理事会;

关键词：

amides; enantioselectivity; iridium catalysis; asymmetric catalysis; hydrogenation; ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; MINIMALLY FUNCTIONALIZED OLEFINS; ASYMMETRIC HYDROGENATION; LIGANDS; ALKYLATION; ALDOL; ENANTIOCONVERGENT; AMIDATION; LACTAMS; NMR;

D O I：

10.1055/s-0042-1751399

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic asymmetric hydrogenation of olefins constitutes a powerful method for the preparation of chiral compounds. A series of prochiral unsaturated amides were efficiently reduced with high enantioselectivities by means of an iridium N,P-complex-catalyzed hydrogenation. Its application in the synthesis of fenpropidin and the possibility of using isomeric mixtures of starting materials are attractive features of the method

引用

页码：1519 / 1523

页数：5

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