NEW CYTOTOXIC NOR- AND BISNORDITERPENE DILACTONES, MAKILACTONES A-D, FROM PODOCARPUS MACROPHYLLUS D. DON

被引：5

作者：

Sato, Kimihiko ^{[1
]}

Sugawara, Keito ^{[1
]}

Takeuchi, Hirono ^{[1
]}

Park, Hyun-Sun ^{[2
]}

Akiyama, Toshiyuki ^{[2
]}

Koyama, Tetsuo ^{[2
]}

Fukaya, Haruhiko ^{[1
]}

Aoyagi, Yutaka ^{[1
]}

Takeya, Koichi ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

[2] Kochi Prefectural Makino Bot Garden, Kochi 7818125, Japan

来源：

HETEROCYCLES | 2009年 / 78卷 / 06期

关键词：

Podocarpus macrophyllus D. Don; Norditerpene Dilactone; Bisnorditerpene Dilactone; 7:8; 9:11-Dienolide Type; Cytotoxic Activity; NORDITERPENE DILACTONES; VAR.-MAKI; INUMAKILACTONE; LEAVES; NAGI;

D O I：

10.3987/COM-08-11624

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new nor- and bisnorditerpene dilactones, makilactones A-D, were isolated from a MeOH extract of bark and root of Podocarpus macrophyllus D. Don (Podocarpaceae) with three known diterpene dilactones. The structures of the new nor- and bisnorditerpene dilactones having a 7:8, 9:11-dienolide Moiety were determined by the spectroscopic studies, including 1D and 2D NMR spectral analysis, and single crystal X-Ray crystallographic analysis. Two of the presently isolated compounds were shown to be very strongly cytotoxic.

引用

页码：1453 / 1462

页数：10

共 46 条

[41] Mandelalides A-D, Cytotoxic Macrolides from a New Lissoclinum Species of South African Tunicate (vol 77, pg 6066, 2012)
Sikorska, Justyna
Hau, Andrew M.
Anklin, Clemens
Parker-Nance, Shirley
Davies-Coleman, Michael T.
Ishmael, Jane E.
McPhail, Kerry L.
JOURNAL OF ORGANIC CHEMISTRY, 2013, 78 (06): : 2812 - 2812
[42] Papuamides A-D, HIV-inhibitory and cytotoxic depsipeptides from the sponges Theonella mirabilis and Theonella swinhoei collected in Papua New Guinea
Ford, PW
Gustafson, KR
McKee, TC
Shigematsu, N
Maurizi, LK
Pannell, LK
Williams, DE
de Silva, ED
Lassota, P
Allen, TM
Van Soest, R
Andersen, RJ
Boyd, MR
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (25) : 5899 - 5909
[43] A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain
Phurpa, Wangchuk
Keller, Paul A.
Pyne, Stephen G.
Lie, Wilford
Willis, Anthony C.
Rattanajak, Roonglawan
Kamchonwongpaisan, Sumalee
JOURNAL OF ETHNOPHARMACOLOGY, 2013, 150 (03) : 953 - 959
[44] Astraodoric Acids A-D: New Lanostane Triterpenes from Edible Mushroom Astraeus odoratus and Their Anti-Mycobacterium tuberculosis H37Ra and Cytotoxic Activity
Arpha, Kittibhorn
Phosri, Cherdchai
Suwannasai, Nuttika
Mongkolthanaruk, Wiyada
Sodngam, Sirirath
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2012, 60 (39) : 9834 - 9841
[45] Begonia difformis comb. & stat. nov (Sect. Platycentrum, Begoniaceae), a new species segregated from B. palmata D. Don
Leong, Wai-Chao
Deng, Tao
Sun, Hang
Peng, Ching-I
Chung, Kuo-Fang
PHYTOTAXA, 2015, 227 (01) : 83 - 91
[46] A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain (vol 150, pg 953, 2013)
Wangchuk, Phurpa
Keller, Paul A.
Pyne, Stephen G.
Lie, Wilford
Willis, Anthony C.
Rattanajak, Roonglawan
Kamchonwongpaisan, Sumalee
JOURNAL OF ETHNOPHARMACOLOGY, 2014, 153 (03) : 934 - 934

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