NEW CYTOTOXIC NOR- AND BISNORDITERPENE DILACTONES, MAKILACTONES A-D, FROM PODOCARPUS MACROPHYLLUS D. DON

被引：5

作者：

Sato, Kimihiko ^{[1
]}

Sugawara, Keito ^{[1
]}

Takeuchi, Hirono ^{[1
]}

Park, Hyun-Sun ^{[2
]}

Akiyama, Toshiyuki ^{[2
]}

Koyama, Tetsuo ^{[2
]}

Fukaya, Haruhiko ^{[1
]}

Aoyagi, Yutaka ^{[1
]}

Takeya, Koichi ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

[2] Kochi Prefectural Makino Bot Garden, Kochi 7818125, Japan

来源：

HETEROCYCLES | 2009年 / 78卷 / 06期

关键词：

Podocarpus macrophyllus D. Don; Norditerpene Dilactone; Bisnorditerpene Dilactone; 7:8; 9:11-Dienolide Type; Cytotoxic Activity; NORDITERPENE DILACTONES; VAR.-MAKI; INUMAKILACTONE; LEAVES; NAGI;

D O I：

10.3987/COM-08-11624

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new nor- and bisnorditerpene dilactones, makilactones A-D, were isolated from a MeOH extract of bark and root of Podocarpus macrophyllus D. Don (Podocarpaceae) with three known diterpene dilactones. The structures of the new nor- and bisnorditerpene dilactones having a 7:8, 9:11-dienolide Moiety were determined by the spectroscopic studies, including 1D and 2D NMR spectral analysis, and single crystal X-Ray crystallographic analysis. Two of the presently isolated compounds were shown to be very strongly cytotoxic.

引用

页码：1453 / 1462

页数：10

共 46 条

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