NEW CYTOTOXIC NOR- AND BISNORDITERPENE DILACTONES, MAKILACTONES A-D, FROM PODOCARPUS MACROPHYLLUS D. DON

被引：5

作者：

Sato, Kimihiko ^{[1
]}

Sugawara, Keito ^{[1
]}

Takeuchi, Hirono ^{[1
]}

Park, Hyun-Sun ^{[2
]}

Akiyama, Toshiyuki ^{[2
]}

Koyama, Tetsuo ^{[2
]}

Fukaya, Haruhiko ^{[1
]}

Aoyagi, Yutaka ^{[1
]}

Takeya, Koichi ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

[2] Kochi Prefectural Makino Bot Garden, Kochi 7818125, Japan

来源：

HETEROCYCLES | 2009年 / 78卷 / 06期

关键词：

Podocarpus macrophyllus D. Don; Norditerpene Dilactone; Bisnorditerpene Dilactone; 7:8; 9:11-Dienolide Type; Cytotoxic Activity; NORDITERPENE DILACTONES; VAR.-MAKI; INUMAKILACTONE; LEAVES; NAGI;

D O I：

10.3987/COM-08-11624

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new nor- and bisnorditerpene dilactones, makilactones A-D, were isolated from a MeOH extract of bark and root of Podocarpus macrophyllus D. Don (Podocarpaceae) with three known diterpene dilactones. The structures of the new nor- and bisnorditerpene dilactones having a 7:8, 9:11-dienolide Moiety were determined by the spectroscopic studies, including 1D and 2D NMR spectral analysis, and single crystal X-Ray crystallographic analysis. Two of the presently isolated compounds were shown to be very strongly cytotoxic.

引用

页码：1453 / 1462

页数：10

共 46 条

[1] Antibacterial Novel Phenolic Diterpenes from Podocarpus macrophyllus D. DON
Sato, Kimihiko
Sugawara, Keito
Takeuchi, Hirono
Park, Hyun-Sun
Akiyama, Toshiyuki
Koyama, Tetsuo
Aoyagi, Yutaka
Takeya, Koichi
Tsugane, Takanori
Shimura, Susumu
CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (12) : 1691 - 1697
[2] Cytotoxic Bisnor- and Norditerpene Dilactones Having 7α,8α-Epoxy-9,11-enolide Substructure from Podocarpus macrophyllus D. DON
Sato, Kimihiko
Inaba, Yasunori
Park, Hyun-Sun
Akiyama, Toshiyuki
Koyama, Tetsuo
Fukaya, Haruhiko
Aoyagi, Yutaka
Takeya, Koichi
CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (07) : 668 - 679
[3] New cytotoxic norditerpene dilactones from leaves of Podocarpus macrophyllus var. maki
Park, HS
Kai, N
Fukaya, H
Aoyagi, Y
Takeya, K
HETEROCYCLES, 2004, 63 (02) : 347 - 357
[4] ISOLATION AND STRUCTURE DETERMINATION OF NORDITERPENE DILACTONES FROM PODOCARPUS-SALIGNA DON,D.
MATLIN, SA
PRAZERES, MA
MERSH, JD
SANDERS, JKM
BITTNER, M
SILVA, M
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1982, (11): : 2589 - 2593
[5] TERMITICIDAL SUBSTANCES FROM WOOD OF PODOCARPUS-MACROPHYLLUS D DON
SAEKI, I
SUMIMOTO, M
KONDO, T
HOLZFORSCHUNG, 1970, 24 (03) : 83 - &
[6] Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa
Chávez, H
Rodríguez, G
Estévez-Braun, A
Ravelo, AG
Estévez-Reyes, R
González, AG
Fdez-Puente, JL
García-Grávalos, D
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (08) : 759 - 762
[7] Rakanmakilactones A-F, new cytotoxic sulfur-containing norditerpene dilactones from leaves of Podocarpus macrophyllus var. maki
Park, HS
Yoda, N
Fukaya, H
Aoyagi, Y
Takeya, K
TETRAHEDRON, 2004, 60 (01) : 171 - 177
[8] CHEMISTRY OF PODOCARPACEAE .8. MACROPHYLLIC ACID, A BISDITERPENOID FROM PODOCARPUS MACROPHYLLUS D.DON
BOCKSSM
CAMBIE, RC
TAKAHASHI, T
TETRAHEDRON, 1963, 19 (06) : 1109 - &
[9] A mosquito larvicidal diterpenoid isolated from Podocarpus totara D.!Don ex Lambert
Lee, SE
Park, EK
Kim, JG
JOURNAL OF ENTOMOLOGICAL SCIENCE, 2000, 35 (04) : 474 - 477
[10] Using morphological attributes for the fast assessment of nutritional responses of Buddhist pine (Podocarpus macrophyllus [Thunb.] D. Don) seedlings to exponential fertilization
Xu, Liang
Zhang, Xie
Zhang, Duhai
Wei, Hongxu
Guo, Jia
PLOS ONE, 2019, 14 (12):

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