Ruthenium-catalyzed enantioselective reduction of electron-rich aryl alkyl ketones

被引：38

作者：

Wettergren, Jenny ^{[1
]}

Bogevig, Anders ^{[1
]}

Portier, Maud ^{[1
]}

Adolfsson, Hans ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 10-11期

关键词：

asymmetric catalysis; hydrogen transfer; ketones; reduction; ruthenium;

D O I：

10.1002/adsc.200606067

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Presented here is the investigation of the transfer hydrogenation of electron-rich aryl alkyl ketones using ruthenium complexes of dipeptide-like ligands and 2-propanol as hydride source. The reduction proceeded with excellent selectivity (up to > 99 % ee) and in moderate to high yields (up to 90%).

引用

页码：1277 / 1282

页数：6

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