Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Propargylic Ketones

被引：10
|
作者：
Shatskiy, Andrey [1 ]
Kivijarvi, Tove [1 ]
Lundberg, Helena [1 ]
Tinnis, Fredrik [1 ]
Adolfsson, Hans [1 ]
机构：
[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, S-10691 Stockholm, Sweden
来源：
CHEMCATCHEM | 2015年 / 7卷 / 23期
基金：
瑞典研究理事会;
关键词：
alkynones; asymmetric catalysis; hydrogenation; propargylic alcohols; ruthenium; ENANTIOSELECTIVE TOTAL-SYNTHESIS; DYNAMIC KINETIC RESOLUTION; SECONDARY ALCOHOLS; ALPHA; BETA-ACETYLENIC KETONES; ALKYNYL KETONES; MECHANISTIC INVESTIGATIONS; ABSOLUTE-CONFIGURATION; LEUCASCANDROLIDE-A; AQUEOUS-MEDIA; REDUCTION;
D O I：
10.1002/cctc.201500821
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The asymmetric transfer hydrogenation of alpha,beta-propargyl ketones catalyzed by an in situ formed ruthenium-hydroxyamide complex was explored. The acetylenic alcohols were isolated in good to excellent yields with excellent ee values (typically >90%) after short reaction times at room temperature.
引用
收藏
页码：3818 / 3821
页数：4
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