Association of G72/G30 with schizophrenia in the Chinese population

被引：75
|
作者：
Wang, XY
He, G
Gu, NF
Yang, JD
Tang, JX
Chen, Q
Liu, XM
Shen, YF
Qian, XQ
Lin, W
Duan, Y
Feng, GY
He, L
机构：
[1] Chinese Acad Sci, SIBS, Inst Nutrit Sci, Shanghai 200031, Peoples R China
[2] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Biox Life Sci Res Ctr, Shanghai 200030, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 319卷 / 04期
基金：
中国国家自然科学基金;
关键词：
schizophrenia; genetics; association; haplotype;
D O I：
10.1016/j.bbrc.2004.05.119
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently, the G72 gene was reported to be associated with schizophrenia in the French Canadian and Russian populations. Here, we report the results obtained from the study of six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs1935062, rs778293, and rs3918342), which span an 82-kb region covering the complementary DNA sequences of G72 and G30, in 537 schizophrenia cases and 538 controls of the Han Chinese. In this work, we have identified statistically significant differences in allele distributions of two markers rs3916965 (P = 0.019) and rs2391191 (P = 0.0010), and a highly significant association between haplotype AGAC of the G72/G30 locus (P = 1.7 x 10(-4)) and schizophrenia. Our data provide further evidence that markers of the G72/G30 genes are associated with schizophrenia in a non-Caucasian population. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：1281 / 1286
页数：6
相关论文
共 50 条
  • [31] The G72/G30 region is implicated in schizophrenia susceptibility in Palestinian families from the North part of Israel
    Cholostoy, A
    Korostishevsky, M
    Kremer, I
    Kaganovich, M
    Murad, I
    Muhaheed, M
    Bannoura, I
    Rietschel, M
    Dobrusin, M
    Belmaker, RH
    Maier, W
    Bening, ASU
    Ebstein, RP
    Navon, R
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 130B (01) : 86 - 86
  • [32] Expression of the G72/G30 gene in transgenic mice induces behavioral changes
    L Cheng
    E Hattori
    A Nakajima
    N S Woehrle
    M D Opal
    C Zhang
    K Grennan
    S C Dulawa
    Y-P Tang
    E S Gershon
    C Liu
    Molecular Psychiatry, 2014, 19 : 175 - 183
  • [33] The G72/G30 gene locus in psychiatric disorders:: A challenge to diagnostic boundaries?
    Jamra, Rami Abou
    Schmael, Christine
    Cichon, Sven
    Rietschel, Marcella
    Schumacher, Johannes
    Noethen, Markus M.
    SCHIZOPHRENIA BULLETIN, 2006, 32 (04) : 599 - 608
  • [34] Expression of the G72/G30 gene in transgenic mice induces behavioral changes
    Cheng, L.
    Hattori, E.
    Nakajima, A.
    Woehrle, N. S.
    Opal, M. D.
    Zhang, C.
    Grennan, K.
    Dulawa, S. C.
    Tang, Y-P
    Gershon, E. S.
    Liu, C.
    MOLECULAR PSYCHIATRY, 2014, 19 (02) : 175 - 183
  • [35] Association between G72/G30 D-amino acid oxidase activator and longitudinal MRI brain volume reductions in schizophrenia
    Ho, Beng-Choon
    Andreasen, Nancy C.
    Wassink, Thomas H.
    NEUROPSYCHOPHARMACOLOGY, 2006, 31 : S114 - S114
  • [36] Schizophrenia and bipolar disorder share at least one common genetic risk locus at G72/G30 region
    Navon, R
    Cholostoy, A
    Kaganovich, M
    Bening-Abu-Shach, U
    Korostishevsky, M
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 130B (01): : 125 - 125
  • [37] Positive association between G72/G30 gene markers on 13Q33 and schizophrenia in the Irish study of high density schizophrenia families (ISHDSF)
    Thiselton, DL
    Wormley, B
    Webb, BT
    Neale, B
    Ribble, RC
    O'Neill, FA
    Walsh, D
    Kendler, KS
    Riley, BP
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 130B (01): : 134 - 134
  • [38] Association study of SNPs in G72 and DAAO in schizophrenia
    Impler, EM
    Dahmen, N
    Giegling, I
    Hartmann, AM
    Möller, HJ
    Rujescu, D
    PHARMACOPSYCHIATRY, 2003, 36 (05) : 237 - 237
  • [39] Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study
    Ohi, Kazutaka
    Hashimoto, Ryota
    Yasuda, Yuka
    Yoshida, Tetsuhiko
    Takahashi, Hidetoshi
    Iike, Naomi
    Fukumoto, Motoyuki
    Takamura, Hironori
    Iwase, Masao
    Kamino, Kouzin
    Ishii, Ryouhei
    Kazui, Hiroaki
    Sekiyama, Ryuji
    Kitamura, Yuri
    Azechi, Michiyo
    Ikezawa, Koji
    Kurimoto, Ryu
    Kamagata, Eiichiro
    Tanimukai, Hitoshi
    Tagami, Shinji
    Morihara, Takashi
    Ogasawara, Masayuki
    Okochi, Masayasu
    Tokunaga, Hiromasa
    Numata, Shusuke
    Ikeda, Masashi
    Ohnuma, Tohru
    Ueno, Shu-ichi
    Fukunaga, Tomoko
    Tanaka, Toshihisa
    Kudo, Takashi
    Arai, Heii
    Ohmori, Tetsuro
    Iwata, Nakao
    Ozaki, Norio
    Takeda, Masatoshi
    SCHIZOPHRENIA RESEARCH, 2009, 109 (1-3) : 80 - 85
  • [40] Transmission disequilibrium and haplotype analyses of the G72/G30 locus: Suggestive linkage to schizophrenia in Palestinian Arabs living in the north of Israel
    Korostishevsky, M
    Kremer, I
    Kaganovich, A
    Cholostoy, A
    Murad, I
    Muhaheed, M
    Bannoura, I
    Rietschel, M
    Dobrusin, M
    Bening-Abu-Shach, U
    Belmaker, RH
    Maier, W
    Ebstein, RP
    Navon, R
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (01) : 91 - 95
12345