Association of G72/G30 with schizophrenia in the Chinese population

被引：75
|
作者：
Wang, XY
He, G
Gu, NF
Yang, JD
Tang, JX
Chen, Q
Liu, XM
Shen, YF
Qian, XQ
Lin, W
Duan, Y
Feng, GY
He, L
机构：
[1] Chinese Acad Sci, SIBS, Inst Nutrit Sci, Shanghai 200031, Peoples R China
[2] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Biox Life Sci Res Ctr, Shanghai 200030, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 319卷 / 04期
基金：
中国国家自然科学基金;
关键词：
schizophrenia; genetics; association; haplotype;
D O I：
10.1016/j.bbrc.2004.05.119
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently, the G72 gene was reported to be associated with schizophrenia in the French Canadian and Russian populations. Here, we report the results obtained from the study of six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs1935062, rs778293, and rs3918342), which span an 82-kb region covering the complementary DNA sequences of G72 and G30, in 537 schizophrenia cases and 538 controls of the Han Chinese. In this work, we have identified statistically significant differences in allele distributions of two markers rs3916965 (P = 0.019) and rs2391191 (P = 0.0010), and a highly significant association between haplotype AGAC of the G72/G30 locus (P = 1.7 x 10(-4)) and schizophrenia. Our data provide further evidence that markers of the G72/G30 genes are associated with schizophrenia in a non-Caucasian population. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：1281 / 1286
页数：6
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