Uromodulin, kidney function, cardiovascular disease, and mortality

被引：21
|
作者：
Devuyst, Olivier [1 ]
Bochud, Murielle [2 ]
机构：
[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland
[2] CHU Vaudois, Univ Lausanne Hosp, Univ Inst Social & Prevent Med, CH-1011 Lausanne, Switzerland
来源：
KIDNEY INTERNATIONAL | 2015年 / 88卷 / 05期
关键词：
ASSOCIATE; VARIANTS;
D O I：
10.1038/ki.2015.267
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Uromodulin (Tamm-Horsfall protein) is exclusively produced by the kidney and is the most abundant protein excreted in normal urine. The level of uromodulin in urine could represent a useful biomarker for renal tubular function. The study of Garimella et al. adds elements into the debate, by suggesting that, in elderly adults, low urinary uromodulin concentrations in spot urine identify people at risk of progressive kidney disease and mortality above and beyond established markers of kidney disease.
引用
收藏
页码：944 / 946
页数：3
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