Efficient solvent- and metal-free Sonogashira protocol catalysed by 1,4-diazabicyclo(2.2.2) octane (DABCO)

被引：44
|
作者：
Luque, Rafael [1 ]
Macquarrie, Duncan J. [1 ]
机构：
[1] Univ York, Green Chem Ctr Excellence, York YO10 5DD, N Yorkshire, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 08期
关键词：
CROSS-COUPLING REACTIONS; SYNTHETIC ORGANIC-CHEMISTRY; BAYLIS-HILLMAN REACTION; COPPER-FREE; ARYL BROMIDES; PD CATALYSTS; PALLADIUM NANOPARTICLES; GREEN CHEMISTRY; LEWIS-BASE; AMINE-FREE;
D O I：
10.1039/b821134p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient metal-free Sonogashira coupling protocol catalysed by DABCO is reported, where very good conversions and selectivities to the cross-coupling product were obtained under mild reaction conditions. The reported solvent-, phosphane- and metal-free protocol, that uses a cheap base as catalyst, considerably improves the green credentials of the reaction.
引用
收藏
页码：1627 / 1632
页数：6
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