Efficient solvent- and metal-free Sonogashira protocol catalysed by 1,4-diazabicyclo(2.2.2) octane (DABCO)

被引：44

作者：

Luque, Rafael ^{[1
]}

Macquarrie, Duncan J. ^{[1
]}

机构：

[1] Univ York, Green Chem Ctr Excellence, York YO10 5DD, N Yorkshire, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 08期

关键词：

CROSS-COUPLING REACTIONS; SYNTHETIC ORGANIC-CHEMISTRY; BAYLIS-HILLMAN REACTION; COPPER-FREE; ARYL BROMIDES; PD CATALYSTS; PALLADIUM NANOPARTICLES; GREEN CHEMISTRY; LEWIS-BASE; AMINE-FREE;

D O I：

10.1039/b821134p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient metal-free Sonogashira coupling protocol catalysed by DABCO is reported, where very good conversions and selectivities to the cross-coupling product were obtained under mild reaction conditions. The reported solvent-, phosphane- and metal-free protocol, that uses a cheap base as catalyst, considerably improves the green credentials of the reaction.

引用

页码：1627 / 1632

页数：6

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