Fluid shear stress induces cell migration and invasion via activating autophagy in HepG2 cells

被引：28

作者：

Yan, Zhiping ^{[1
]}

Su, Guanyue ^{[1
]}

Gao, Wenbo ^{[1
]}

He, Jia ^{[1
]}

Shen, Yang ^{[1
]}

Zeng, Ye ^{[1
]}

Liu, Xiaoheng ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Inst Biomed Engn, 17,Sect 3,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China

来源：

CELL ADHESION & MIGRATION | 2019年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Fluid shear stress; autophagy; integrin; cytoskeleton; metastasis;

D O I：

10.1080/19336918.2019.1568141

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fluid shear stress (FSS) regulates the metastasis of hepatocellular carcinoma (HCC). In the present study, we aimed to study the role of autophagy in HCC cells under FSS. The results showed that FSS upregulated the protein markers of autophagy, induced LC3B aggregation and formation of autophagosomes. Inhibition of integrin by Cliengitide (Cli) or inhibition of the microfilaments formation both inhibited the activation of autophagy in HepG2 under FSS. In addition, Cli inhibited the microfilaments formation and expressions of Rac1 and RhoA in HepG2 cells under FSS. Finally, inhibition of autophagy suppressed the cell migration and invasion in HepG2 under FSS. In conclusion, FSS induced autophagy to promote migration and invasion of HepG2 cells via integrin/cytoskeleton pathways.

引用

页码：152 / 162

页数：11

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