The area postrema mediates insulin hypoglycaemia-induced suppression of pulsatile LH secretion in the female rat

被引：36

作者：

Cates, PS ^{[1
]}

O'Byrne, KT ^{[1
]}

机构：

[1] Kings Coll London, GKT Sch Biomed Sci, Div Anat Cell & Human Biol, London SE1 1UL, England

来源：

BRAIN RESEARCH | 2000年 / 853卷 / 01期

基金：

英国医学研究理事会;

关键词：

area postrema; luteinising hormone; hypoglycaemia; GnRH;

D O I：

10.1016/S0006-8993(99)02301-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The caudal brainstem has been implicated in mediating the suppressive effect of glucoprivation on the reproductive neuroendocrine axis, specifically inhibition of pulsatile gonadotrophin-releasing hormone (GnRH)/luteinising hormone (LH) release in the rat. In the present study, removal of the area postrema completely prevented the profound inhibitory effect of insulin-induced hypoglycaemic stress on pulsatile LH release. These results suggest a pivotal role for this brainstem structure in mediating hypoglycaemic stress-induced suppression of the hypothalamic GnRH pulse generator. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：151 / 155

页数：5

共 45 条

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[36] Prostaglandin synthesis mediates the suppression of arcuate Kiss1 neuron activation and pulsatile luteinizing hormone secretion during immune/inflammatory stress in female mice
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[40] Interleukin-13 counteracts suppression induced by Interleukin-1β of glucose metabolism but not of insulin secretion in rat pancreatic islets
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