The area postrema mediates insulin hypoglycaemia-induced suppression of pulsatile LH secretion in the female rat

被引：36
|
作者：
Cates, PS [1 ]
O'Byrne, KT [1 ]
机构：
[1] Kings Coll London, GKT Sch Biomed Sci, Div Anat Cell & Human Biol, London SE1 1UL, England
来源：
BRAIN RESEARCH | 2000年 / 853卷 / 01期
基金：
英国医学研究理事会;
关键词：
area postrema; luteinising hormone; hypoglycaemia; GnRH;
D O I：
10.1016/S0006-8993(99)02301-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The caudal brainstem has been implicated in mediating the suppressive effect of glucoprivation on the reproductive neuroendocrine axis, specifically inhibition of pulsatile gonadotrophin-releasing hormone (GnRH)/luteinising hormone (LH) release in the rat. In the present study, removal of the area postrema completely prevented the profound inhibitory effect of insulin-induced hypoglycaemic stress on pulsatile LH release. These results suggest a pivotal role for this brainstem structure in mediating hypoglycaemic stress-induced suppression of the hypothalamic GnRH pulse generator. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：151 / 155
页数：5
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