Micronutrients influencing the immune response in leprosy

被引：15

作者：

Passos Vazquez, Cecilia Maria ^{[1
]}

Mendes Netto, Raquel Simoes ^{[2
]}

Ferreira Barbosa, Kiriaque Barra ^{[2
]}

Rodrigues de Moura, Tatiana ^{[1
]}

Pacheco de Almeida, Roque ^{[1
,3
]}

Duthie, Malcolm S. ^{[4
]}

Ribeiro de Jesus, Amelia ^{[1
,3
]}

机构：

[1] Univ Fed Sergipe, Dept Med, Univ Hosp, Mol Biol Lab, Aracaju, Brazil

[2] Univ Fed Sergipe, Dept Nutr, Aracaju, Brazil

[3] CNPq, Inst Nacionais Ciencia & Tecnol, Inst Invest Imunol, Brasilia, DF, Brazil

[4] IDRI, Seattle, WA 98014 USA

来源：

NUTRICION HOSPITALARIA | 2014年 / 29卷 / 01期

关键词：

Nutrition; Leprosy; Oxidative stress and antioxidants; PULMONARY TUBERCULOSIS PATIENTS; D-RECEPTOR GENE; CD4(+) T-CELLS; VITAMIN-D; CATHELICIDIN LL-37; OXIDATIVE STRESS; HANSENS-DISEASE; GREATER VITORIA; ESPIRITO-SANTO; TRACE-ELEMENTS;

D O I：

10.3305/nh.2014.29.1.6988

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an intracellular bacillus of airborne transmission. The disease affects the skin and peripheral nerves and can cause neurological sequelae. The bacillus multiplies slowly in the host and the disease probably occurs due to malfunctioning in host immune response. This review addresses the role of some specific micronutrients in the immune response, such as Vitamins A, D, E, C, Zinc and Selenium, detailing their mechanisms of actions in infectious diseases, and in leprosy. The immune response to pathogens releases harmful substances, which lead to tissue damage. This review discusses how a decreased level of antioxidants may contribute to an increased oxidative stress and complications of infectious diseases and leprosy. As the nutrients have a regulatory effect in the innate and adaptative immune responses, a perfect balance in their concentrations is important to improve the immune response against the pathogens.

引用

页码：26 / 36

页数：11

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