P2O5/SiO2 as an Efficient, Green and Heterogeneous Catalytic System for the Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones (and -Thiones)

被引：23

作者：

Hasaninejad, Alireza ^{[1
]}

Zare, Abdolkarim ^{[2
]}

Jafari, Farhad ^{[2
]}

Moosavi-Zare, Ahmad Reza ^{[2
]}

机构：

[1] Persian Gulf Univ, Dept Chem, Fac Sci, Bushehr 75169, Iran

[2] PNU, Dept Chem, Coll Sci, Bushehr 1698, Iran

来源：

E-JOURNAL OF CHEMISTRY | 2009年 / 6卷 / 02期

关键词：

P2O5/SiO2; Solvent-free; 3,4-Dihydropyrimidin-2-(1H)-one; 3,4-Dihydropyrimidin-2-(1H)-thione; Biginelli reaction; ONE-POT SYNTHESIS; ASSISTED MICHAEL ADDITION; ALPHA; BETA-UNSATURATED ESTERS; REUSABLE CATALYST; HIGHLY EFFICIENT; ZINC-OXIDE; MICROWAVE IRRADIATION; CARBONYL-COMPOUNDS; ACID-ESTERS; CONDENSATION;

D O I：

10.1155/2009/303781

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, green and efficient solventless procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (and -thiones) from aldehydes, beta-ketoesters and urea or thiourea in the presence of catalytic amount of silica-supported P2O5 (P2O5/SiO2) at 85 degrees C is described. Using this method, the title compounds were produced in high yields.

引用

页码：459 / 465

页数：7

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