TaBr5-catalyzed Biginelli reaction:: one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions

被引：100
|
作者：
Ahmed, Naseem [1 ]
van Lier, Johan E. [1 ]
机构：
[1] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med Nucl & Radiobiol, Sherbrooke, PQ J1H 5N4, Canada
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 31期
基金：
加拿大健康研究院;
关键词：
TaBr5-catalyzed Biginelli reaction; solvent-free conditions; 3,4-dihydropyrirnidin-2-(1H)-ones/thiones;
D O I：
10.1016/j.tetlet.2007.06.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient TaBr5 (5-10 mol %)-catalyzed Biginelli reaction under solvent-free conditions for one-pot syntheses of 3,4-dilhydropyrimidin-2-(] H)-ones (DHPMs) and their thione analogs is reported. The catalyst is stable at room temperature and employed under mild and environmentally friendly conditions. (c) 2007 Elsevier Ltd. All rights reserved.
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页码：5407 / 5409
页数：3
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