Pembrolizumab versus cetuximab, concomitant with radiotherapy (RT) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC): Results of the GORTEC 2015-01 "PembroRad" randomized trial

被引：51
|
作者：
Bourhis, J. [1 ]
Sire, C. [2 ]
Tao, Y. [3 ]
Martin, L. [4 ]
Alfonsi, M. [5 ]
Prevost, J. B. [6 ]
Rives, M. [7 ]
Lafond, C. [8 ]
Tourani, J. M. [9 ]
Biau, J. [10 ]
Geoffrois, L. [11 ]
Coutte, A. [12 ]
Liem, X. [13 ]
Vauleon, E. [14 ]
Drouet, F. [15 ]
Pechery, A. [16 ]
Guigay, J. [17 ]
Wanneveich, M. [16 ]
Auperin, A. [3 ]
Sun, X. [18 ]
机构：
[1] CHU Vaudois, Radiat Oncol, Lausanne, Switzerland
[2] CHU Bretagne Sud, Lorient, France
[3] Inst Gustave Roussy, Radiat Oncol, Villejuif, France
[4] Clin Ormeaux, Le Havre, France
[5] Inst St Catherine, Avignon, France
[6] Ctr Pierre Curie, Beuvry, France
[7] Inst Claudius Regaud, Toulouse, France
[8] Clin Victor Hugo, Le Mans, France
[9] CHU Poitiers, Hop Jean Bernard, Poitiers, France
[10] Ctr Lutte Canc J Perrin, Clermont Ferrand, France
[11] Inst Cancerol Lorraine Alexis Vautrin, Med Oncol, Vandoeuvre Les Nancy, France
[12] CHU Amiens Picardie Site Sud, Radiat Oncol, Amiens, France
[13] Ctr Oscar Lambret, Radiotherapy, Lille, France
[14] Ctr Eugene Marquis, Rennes, France
[15] Clin Mutualiste Estuaire, St Nazaire, France
[16] CHU Bretonneau, GORTEC, Tours, France
[17] Ctr Anticanc Antoine Lacassagne, Med Oncol Dept, Nice, France
[18] Hop Nord Franche Comte, Belfort, France
来源：
ANNALS OF ONCOLOGY | 2020年 / 31卷
关键词：
D O I：
10.1016/j.annonc.2020.08.2268
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LBA38
引用
收藏
页码：S1168 / S1168
页数：1
相关论文
共 50 条
  • [41] Neoadjuvant pembrolizumab in surgically resectable, locally advanced HPV negative head and neck squamous cell carcinoma (HNSCC).
    Uppaluri, Ravindra
    Zolkind, Paul
    Lin, Tianxiang
    Nussenbaum, Brian
    Jackson, Ryan S.
    Rich, Jason
    Pipkorn, Patrik
    Paniello, Randal
    Thorstad, Wade
    Michel, Loren
    Mudianto, Tenny
    Oppelt, Peter John
    Wildes, Tanya Marya
    Dunn, Gavin P.
    Piccirillo, Jay F.
    Kallogjeri, Donna
    Rodig, Scott
    Hagemann, Ian S.
    Chernock, Rebecca
    Adkins, Douglas
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [42] Phase I trial of cetuximab, intensity modulated radiotherapy (IMRT), and ipilimumab in previously untreated, locally advanced head and neck squamous cell carcinoma (PULA HNSCC)
    Ferris, R. L.
    Clump, D. A.
    Ohr, J.
    Gooding, W.
    Kim, S.
    Karlovits, B. J.
    Duvvuri, U.
    Johnson, J. T.
    Petro, D.
    Heron, D. E.
    Bauman, J.
    ANNALS OF ONCOLOGY, 2017, 28
  • [43] Phase I trial of cetuximab, intensity modulated radiotherapy (IMRT), and ipilimumab in previously untreated, locally advanced head and neck squamous cell carcinoma (PULA HNSCC)
    Bauman, J.
    Ferris, R. L.
    Clump, D. A.
    Ohr, J.
    Gooding, W.
    Kim, S.
    Karlovits, B.
    Duvvuri, U.
    Johnson, J. T.
    Petro, D.
    Heron, D.
    ANNALS OF ONCOLOGY, 2016, 27
  • [44] Cetuximab and Radiotherapy Versus Cisplatin and Radiotherapy for Locally Advanced Head and Neck Cancer: A Randomized Phase II Trial
    Magrini, Stefano Maria
    Buglione, Michela
    Corvo, Renzo
    Pirtoli, Luigi
    Paiar, Fabiola
    Ponticelli, Pietro
    Petrucci, Alessia
    Bacigalupo, Almalina
    Crociani, Monica
    Lastrucci, Luciana
    Vecchio, Stefania
    Bonomo, Pierluigi
    Pasinetti, Nadia
    Triggiani, Luca
    Cavagnini, Roberta
    Costa, Loredana
    Tonoli, Sandro
    Maddalo, Marta
    Grisanti, Salvatore
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (05) : 427 - +
  • [45] Accelerated radiotherapy and concomitant high dose chemotherapy in non resectable stage IV locally advanced HNSCC: Results of a GORTEC randomized trial
    Bourhis, Jean
    Lapeyre, Michel
    Tortochaux, Jacques
    Lusinchi, Antoine
    Etessami, Atoussa
    Ducourtieux, Murielle
    Geoffrois, Lionel
    Domenge, Christian
    Verrelle, Pierre
    Wibault, Pierre
    Janot, Francois
    Temam, Stephane
    Blanchard, Pierre
    Tao, Yun G.
    Auperin, Anne
    RADIOTHERAPY AND ONCOLOGY, 2011, 100 (01) : 56 - 61
  • [46] Response-adapted volume de-escalation (RAVD) of radiotherapy (RT) using induction chemotherapy (IC) in locally advanced head and neck squamous cell cancer (LA-HNSCC)
    Villaflor, Victoria Meucci
    Cohen, Ezra E. W.
    Melotek, James M.
    Brisson, Ryan J.
    Karrison, Theodore
    Blair, Elizabeth A.
    Portugal, Louis
    Stenson, Kerstin
    De Souza, Jonas A.
    Langerman, Alexander
    Seiwert, Tanguy Y.
    Vokes, Everett E.
    Haraf, Daniel J.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [47] Feasibility of concomitant cisplatin with hypofractionated radiotherapy for locally advanced head and neck squamous cell carcinoma
    Jacinto, Alexandre Arthur
    Batalha Filho, Eronides Salustiano
    Viana, Luciano de Souza
    De Marchi, Pedro
    Capuzzo, Renato de Castro
    Gama, Ricardo Ribeiro
    Boldrini Junior, Domingos
    Santos, Carlos Roberto
    Junqueira Pinto, Gustavo Dix
    Dias, Josiane Mourao
    Canton, Heloisa Pelisser
    Carvalho, Raiany
    Radicchi, Lucas Augusto
    Bentzen, Soren
    Zubizarreta, Eduardo
    Carvalho, Andre Lopes
    BMC CANCER, 2018, 18
  • [48] CHRONOMODULATED CHEMOTHERAPY AND CONCOMITANT RADIOTHERAPY, FOR THE MANAGEMENT OF LOCALLY ADVANCED, HEAD AND NECK SQUAMOUS CELL CARCINOMA
    Verma, Yashpal
    Chauhan, Ashok K.
    Singh, Harmeet
    Sabharwal, Ramesh
    Bharti, Mukesh
    Kaur, Paramjeet
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2014, 5 (03): : 1015 - 1022
  • [49] Efficacy and Safety of Aprepitant for the Prevention of Nausea and Emesis During Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC): A Phase 2 Trial
    Zhang, Y.
    Yi, J.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2020, 108 (03): : S108 - S109
  • [50] Accelerated radiotherapy with delayed concomitant boost in locally advanced squamous cell carcinoma of the head and neck
    MacKenzie, R
    Balogh, J
    Choo, R
    Franssen, E
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1999, 45 (03): : 589 - 595
12345