Pembrolizumab versus cetuximab, concomitant with radiotherapy (RT) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC): Results of the GORTEC 2015-01 "PembroRad" randomized trial

被引:51
|
作者
Bourhis, J. [1 ]
Sire, C. [2 ]
Tao, Y. [3 ]
Martin, L. [4 ]
Alfonsi, M. [5 ]
Prevost, J. B. [6 ]
Rives, M. [7 ]
Lafond, C. [8 ]
Tourani, J. M. [9 ]
Biau, J. [10 ]
Geoffrois, L. [11 ]
Coutte, A. [12 ]
Liem, X. [13 ]
Vauleon, E. [14 ]
Drouet, F. [15 ]
Pechery, A. [16 ]
Guigay, J. [17 ]
Wanneveich, M. [16 ]
Auperin, A. [3 ]
Sun, X. [18 ]
机构
[1] CHU Vaudois, Radiat Oncol, Lausanne, Switzerland
[2] CHU Bretagne Sud, Lorient, France
[3] Inst Gustave Roussy, Radiat Oncol, Villejuif, France
[4] Clin Ormeaux, Le Havre, France
[5] Inst St Catherine, Avignon, France
[6] Ctr Pierre Curie, Beuvry, France
[7] Inst Claudius Regaud, Toulouse, France
[8] Clin Victor Hugo, Le Mans, France
[9] CHU Poitiers, Hop Jean Bernard, Poitiers, France
[10] Ctr Lutte Canc J Perrin, Clermont Ferrand, France
[11] Inst Cancerol Lorraine Alexis Vautrin, Med Oncol, Vandoeuvre Les Nancy, France
[12] CHU Amiens Picardie Site Sud, Radiat Oncol, Amiens, France
[13] Ctr Oscar Lambret, Radiotherapy, Lille, France
[14] Ctr Eugene Marquis, Rennes, France
[15] Clin Mutualiste Estuaire, St Nazaire, France
[16] CHU Bretonneau, GORTEC, Tours, France
[17] Ctr Anticanc Antoine Lacassagne, Med Oncol Dept, Nice, France
[18] Hop Nord Franche Comte, Belfort, France
关键词
D O I
10.1016/j.annonc.2020.08.2268
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
LBA38
引用
收藏
页码:S1168 / S1168
页数:1
相关论文
共 50 条
  • [21] Response of chemoradiation therapy after induction chemotherapy failure in locally advanced head and neck squamous cell carcinoma (LA-HNSCC).
    Lim, Yoojoo
    Keam, Bhumsuk
    Koh, Youngil
    Lee, Kyung-Hun
    Kim, Tae Min
    Lee, Se-Hoon
    Hah, Jeong-Hun
    Kwon, Tack-Kyun
    Kim, Dong-Wan
    Wu, Hong-Gyun
    Sung, Myung-Whun
    Heo, Dae Seog
    Kim, Kwang Hyun
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [22] Treatment patterns in elderly patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC): Results from an EORTC led survey
    Oosting, S.
    Desideri, I.
    Staelens, D.
    Caballero, C.
    Tribius, S.
    Simon, C.
    Singer, S.
    Gregoire, V.
    Fortpied, C.
    Luciani, A.
    ANNALS OF ONCOLOGY, 2018, 29 : 393 - 393
  • [23] Concomitant chemoradiation or RT/cetuximab versus induction TPF followed by chemoradiation or RT/cetuximab in locally advanced head and neck squamous cell carcinoma: A randomized phase III factorial study.
    Paccagnella, A.
    Ghi, M. G.
    Floriani, I.
    Gava, A.
    Buffoli, A.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
  • [24] Multimodal detection in plasma of molecular residual disease (MRD) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC).
    Garcia, Enrique Sanz
    Zou, Jinfeng
    Avery, Lisa
    Spreafico, Anna
    Waldron, John
    Goldstein, David Paul
    Hansen, Aaron Richard
    Cho, John
    de Almeida, John R.
    Hope, Andrew
    Hosni, Ali
    Hahn, Ezra
    Perez-Ordonez, Bayardo
    Zhao, Zhen
    Smith, Christopher Gareth
    Zheng, Yangqiao
    Rosenfeld, Nitzan
    Singaravelan, Nittusha
    Bratman, Scott Victor
    Siu, Lillian L.
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [25] Randomized phase II trial of concomitant chemoradiotherapy (CT/RT) versus docetaxel, cisplatin and 5-fluorouracil (TPF) followed by concomitant CT/RT in locally advanced head and neck squamous cell carcinoma (HNSCC)
    Turcato, G.
    Buffoli, A.
    Loreggian, L.
    Gava, A.
    Campostrini, F.
    Gardani, G.
    Polsinelli, M.
    Tomio, L.
    Villa, B.
    Paccagnella, A.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 66 (03): : S192 - S192
  • [26] Concurrent cisplatin and dose escalation with intensity-modulated radiotherapy (IMRT) versus conventional radiotherapy for locally advanced head and neck squamous cell carcinomas (HNSCC): GORTEC 2004-01 randomized phase III trial
    Tao, Yungan
    Auperin, Anne
    Blanchard, Pierre
    Alfonsi, Marc
    Sun, Xu-Shan
    Rives, Michel
    Pointreau, Yoann
    Castelli, Joel
    Graff, Pierre
    Kam, Stephanie Wong Hee
    Thariat, Juliette
    Veresezan, Ovidiu
    Heymann, Steve
    Renard-Oldrini, Sophie
    Lafond, Cedrik
    Cornely, Alexandre
    Casiraghi, Odile
    Boisselier, Pierre
    Lapeyre, Michel
    Biau, Julian
    Bourhis, Jean
    RADIOTHERAPY AND ONCOLOGY, 2020, 150 : 18 - 25
  • [27] Phase II Study of Cetuximab With Concomitant-boost Radiotherapy (RT) in Japanese Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (LA-SCCHN)
    Fujii, M.
    Yoshino, T.
    Onozawa, Y.
    Kodaira, T.
    Ota, M.
    Gross, A.
    Tsukuda, M.
    Tahara, M.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S564 - S565
  • [28] Cetuximab plus radiotherapy for the treatment of locally advanced squamous cell carcinoma of the head and neck
    Griffin, S.
    Walker, S.
    Sculpher, M.
    White, S.
    Erhorn, S.
    Brent, S.
    Dyker, A.
    Ferrie, L.
    Gilfillan, C.
    Horsley, W.
    Macfarlane, K.
    Thomas, S.
    HEALTH TECHNOLOGY ASSESSMENT, 2009, 13 : 49 - 54
  • [29] Gemcitabine versus cisplatin concomitant with radiotherapy for locally advanced squamous cell carcinoma of the head and neck.
    Ali, Elsayed Mostafa
    Hassan, Emad Nabil
    Elyamany, Ashraf
    Maklad, Ahmed M.
    Abdelraheem, Ahmed Gaber
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [30] Concurrent cisplatin and dose escalation with intensity-modulated radiotherapy (IMRT) versus conventional chemo-radiotherapy for locally advanced (LA) head and neck squamous cell carcinomas (HNSCC): GORTEC 2004-01 randomized phase III trial
    Tao, Y.
    Auperin, A.
    Blanchard, P.
    Alfonsi, M.
    Sun, X-S.
    Rives, M.
    Pointreau, Y.
    Castelli, J.
    Graff, P.
    Kam, S. Wong Hee
    Thariat, J.
    Veresezan, O.
    Cornely, A.
    Casiraghi, O.
    Lapeyre, M.
    Bourhis, J.
    ANNALS OF ONCOLOGY, 2018, 29