Bispecific Anti-CD123 x Anti-CD3 Adaptir™ Molecules APVO436 and APVO437 Have Broad Activity Against Primary Human AML Cells In Vitro

被引：0
|
作者：
Godwin, Colin D.
Bates, Olivia M.
Laszlo, George S.
Gottschalk, Rebecca
Comeau, Michael R.
Hoyos, Gabriela H.
Walter, Roland B.
机构：
来源：
BLOOD | 2017年 / 130卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2639
引用
收藏
页数：2
相关论文
共 38 条
  • [31] Ex-vivo exposure-response characterization of antitumor activity of anti CD123 X CD3 DuoBody in primary acute myeloid leukemia (AML) bone marrow samples
    Singh, Indrajeet
    Parab, Nikita
    Syed, Khaja
    Jiang, Xiling
    Sun, Yu-Nien
    Huang, Fei
    Sasser, Kate
    Kalota, Anna
    JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2017, 44 : S40 - S40
  • [32] The Anti-Tumor Activity Role of CD3+CD56+Against Human Chronic Myelocytic Leukemia K562 Cells Line In Vitro
    Osadolor, I. O.
    Rodriguez, M. S.
    Sanchez, L. H.
    Leal, T. S.
    TRANSFUSION, 2011, 51 : 234A - 234A
  • [33] BISPECIFIC ANTIBODY-DIRECTED ANTITUMOR-ACTIVITY OF HUMAN CD4+ HELPER KILLER T-CELLS INDUCED BY ANTI-CD3 MONOCLONAL-ANTIBODY PLUS INTERLEUKIN-2
    NISHIMURA, T
    NAKAMURA, Y
    TAKEUCHI, Y
    GAO, XH
    TOKUDA, Y
    OKUMURA, K
    HABU, S
    JAPANESE JOURNAL OF CANCER RESEARCH, 1991, 82 (11): : 1207 - 1210
  • [34] Affinity tuned Xmab®2+1 anti-mesothelin x anti-CD3 bispecific antibody induces selective T cell-dependent cellular cytotoxicity of human ovarian cancer cells
    Zeng, Veronica G.
    Faber, Matthew S.
    Bernett, Matthew J.
    Avery, Kendra N.
    Zeytounian, John L.
    Rashid, Rumana
    Muchhal, Umesh S.
    Moore, Gregory L.
    Desjarlais, John R.
    Hedvat, Michael
    CANCER RESEARCH, 2020, 80 (16)
  • [35] Extracellular domain of 4-1BBL enhanced the antitumoral efficacy of peripheral blood lymphocytes mediated by anti-CD3 x anti-Pgp bispecific diabody against human multidrug-resistant leukemia
    Guo, Hongxing
    Jiang, Wenguo
    Liu, Wenge
    Gao, Yingdai
    Yang, Ming
    Zhou, Yuan
    Wang, Jinhong
    Qi, Jing
    Cheng, Xin
    Zhu, Zhenping
    Yang, Chunzheng
    Xiong, Dongsheng
    CELLULAR IMMUNOLOGY, 2008, 251 (02) : 102 - 108
  • [36] Immunotherapy with Anti-CD3 x Anti-CMV Bispecific Antibody (CMVBi) Armed Donor Derived Activated T Cells (ATC) - A Novel Strategy against Cytomegalovirus (CMV) Post Allogeneic Stem Cell Transplantation (SCT).
    Ramesh, Mayur S.
    Thakur, Archana
    Pellett, Philip
    Das, Subhendu
    Al-Kadhimi, Zaid S.
    Lum, Lawrence G.
    BLOOD, 2009, 114 (22) : 475 - 476
  • [37] Immunotherapy with Long-Lived Anti-CD20 x Anti-CD3 Bispecific Antibodies Stimulates Potent T Cell-Mediated Killing of Human B Cell Lines and of Circulating and Lymphoid B Cells in Monkeys: A Potential Therapy for B Cell Lymphomas and Leukemias
    Chu, Seung Y.
    Lee, Sung-Hyung
    Rashid, Rumana
    Chen, Hsing
    Chan, Emily W.
    Phung, Sheryl
    Pong, Erik
    Endo, Nancy A.
    Miranda, Yvonne
    Bonzon, Christine
    Leung, Irene W. L.
    Muchhal, Umesh S.
    Moore, Gregory L.
    Bernett, Matthew J.
    Szymkowski, David E.
    Desjarlais, John R.
    BLOOD, 2014, 124 (21)
  • [38] ATOR-4066, a Neo-X-Prime bispecific antibody targeting CD40 and CEA, activates myeloid cells in primary human tumors in vitro and induces anti-tumor immunity in vivo
    Hagerbrand, Karin
    Sundstedt, Anette
    Levin, Mattias
    de Coana, Yago Pico
    Varas, Laura
    Ljung, Lill
    Nilsson, Anneli
    Celander, Mona
    Jimenez, David Gomez
    Andersson, Hampus
    Lindstedt, Malin
    Ellmark, Peter
    CANCER RESEARCH, 2023, 83 (07)
1234