Bispecific Anti-CD123 x Anti-CD3 Adaptir™ Molecules APVO436 and APVO437 Have Broad Activity Against Primary Human AML Cells In Vitro

被引：0
|
作者：
Godwin, Colin D.
Bates, Olivia M.
Laszlo, George S.
Gottschalk, Rebecca
Comeau, Michael R.
Hoyos, Gabriela H.
Walter, Roland B.
机构：
来源：
BLOOD | 2017年 / 130卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2639
引用
收藏
页数：2
相关论文
共 38 条
  • [21] Purified anti-CD3 x anti-HER2 bispecific antibody potentiates cytokine-induced killer cells of poor spontaneous cytotoxicity against breast cancer cells
    He, Qingzhong
    Zhang, Haisong
    Wang, Youzhao
    Ting, Hong Hoi
    Yu, Wenhua
    Cao, Xuetao
    Ge, Wei
    CELL AND BIOSCIENCE, 2014, 4
  • [22] SPECIFIC TARGETING OF INVITRO-ACTIVATED HUMAN ANTITUMOR EFFECTOR-CELLS USING ANTI-CD3 X ANTI-C-ERBB-2 BISPECIFIC ANTIBODY
    TSUKAMOTO, H
    NAKAMURA, Y
    MASUKO, T
    HASHIMOTO, Y
    HABU, S
    NISHIMURA, T
    IMMUNOLOGY AND CELL BIOLOGY, 1993, 71 : 109 - 115
  • [23] Bispecific anti-CD3 x anti-HER2 antibody mediates T cell cytolytic activity to HER2-positive colorectal cancer in vitro and in vivo
    Han, Huamin
    Ma, Juan
    Zhang, Keming
    Li, Wei
    Liu, Changzhen
    Zhang, Yu
    Zhang, Ganlin
    Ma, Pan
    Wang, Lei
    Zhang, Ge
    Tao, Hua
    Gao, Bin
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 45 (06) : 2446 - 2454
  • [24] Activated T cells armed with anti-CD3 x anti-HER2/neu bispecific antibody I:: Anti-tumor activity and survival in SCID/Beige mice.
    Smith, JA
    Davol, PA
    Kouttab, NM
    Rathore, R
    Elfenbein, GJ
    Lum, LG
    BLOOD, 2002, 100 (11) : 673A - 673A
  • [25] Novel anti-CD33 immunoconjugate demonstrating in vitro and in vivo activity against human acute myeloid leukemia (AML) cells.
    Hebib, Nadia C.
    Larochelle, Fannie
    Lutz, Bob
    Lambert, John
    Blattler, Walter
    Roy, Denis Claude
    CANCER RESEARCH, 2006, 66 (08)
  • [26] Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model
    Reusch, U
    Sundaram, M
    Davol, PA
    Olson, SD
    Davis, JB
    Demel, K
    Nissim, J
    Rathore, R
    Liu, PY
    Lum, LG
    CLINICAL CANCER RESEARCH, 2006, 12 (01) : 183 - 190
  • [27] USE OF BISPECIFIC MABS, ANTI-CD3/ANTI-EGF-R, TO RETARGET HUMAN ACTIVATED LYMPHOCYTES-T AGAINST TUMOR-CELLS OVER-EXPRESSING EGF-R
    MEZZANZANICA, D
    POMPEN, M
    CANEVARI, S
    FERRINI, S
    CAMBIAGGI, A
    MORETTA, L
    COLNAGHI, MI
    FASEB JOURNAL, 1992, 6 (05): : A2059 - A2059
  • [28] Immunotherapy with Long-Lived Anti-CD38 x Anti-CD3 Bispecific Antibodies Stimulates Potent T Cell-Mediated Killing of Human Myeloma Cell Lines and CD38+Cells in Monkeys: A Potential Therapy for Multiple Myeloma
    Chu, Seung Y.
    Miranda, Yvonne
    Phung, Sheryl
    Chen, Hsing
    Rashid, Rumana
    Endo, Nancy A.
    Chan, Emily W.
    Pong, Erik
    Bonzon, Christine
    Muchhal, Umesh S.
    Leung, Irene W. L.
    Bernett, Matthew J.
    Moore, Gregory L.
    Szymkowski, David E.
    Desjarlais, John R.
    BLOOD, 2014, 124 (21)
  • [29] Clinical Activity of REGN1979, a Bispecific Human, Anti-CD20 x Anti-CD3 Antibody, in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL)
    Bannerji, Rajat
    Allan, John N.
    Arnason, Jon E.
    Brown, Jennifer R.
    Advani, Ranjana H.
    Barnes, Jeffrey A.
    Ansell, Stephen M.
    O'Brien, Susan M.
    Chavez, Julio
    Duell, Johannes
    David, Kevin A.
    Martin, Peter
    Joyce, Robin M.
    Charnas, Robert
    Ambati, Srikanth R.
    Adriaens, Lieve
    Ufkin, Melanie
    Zhu, Min
    Li, Jingjin
    Gasparini, Peter
    Ibrahim, Anfal
    Jankovic, Vladimir
    Fiaschi, Nathalie
    Aina, Olulanu
    Zhang, Wen
    Deering, Raquel P.
    Hamon, Sara
    Thurston, Gavin
    Murphy, Andrew J.
    Weinreich, David M.
    Yancopoulos, George D.
    Lowy, Israel
    Sternberg, David
    Topp, Max S.
    BLOOD, 2019, 134
  • [30] Anti-SSTR2 x anti-CD3 bispecific antibody induces potent killing of human tumor cells in vitro and in mice, and stimulates target-dependent T cell activation in monkeys: A potential immunotherapy for neuroendocrine tumors
    Lee, Sung-Hyung
    Chu, Seung Y.
    Rashid, Rumana
    Phung, Sheryl
    Leung, Irene W.
    Muchhal, Umesh S.
    Moore, Gregory L.
    Bernett, Matthew J.
    Schubbert, Suzanne
    Ardila, Connie
    Bonzon, Christine
    Foster, Paul
    Szymkowski, David E.
    Desjarlais, John R.
    CANCER RESEARCH, 2017, 77
1234