Rolloamides A and B, Cytotoxic Cyclic Heptapeptides Isolated from the Caribbean Marine Sponge Eurypon laughlini

被引：39

作者：

Williams, David E. ^{[1
,2
]}

Yu, Ker ^{[3
]}

Behrisch, Hans W. ^{[5
]}

Van Soest, Rob ^{[4
]}

Andersen, Raymond J. ^{[1
,2
]}

机构：

[1] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1, Canada

[3] Wyeth Res, Discovery Oncol, Pearl River, NY 10965 USA

[4] Univ Amsterdam, Inst Systemat & Populat Biol, Zool Museum, Dept Coelenterates & Porifera, NL-1090 AT Amsterdam, Netherlands

[5] Ross Univ, Sch Med, Portsmouth, Commonwealth Do, Dominica

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 07期

关键词：

PROLINE; OCTAPEPTIDE; PEPTIDES; PORIFERA;

D O I：

10.1021/np900121m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two cyclic heptapeptides, rolloamides A (1) and B (2), have been isolated from the Dominican marine sponge Eurypon laughlini. The structures of 1 and 2 were elucidated by a combination of spectroscopic analyses and chemical degradation. Rolloamide A (1), which was found to exist as two distinct conformers in C5D5N, exhibits growth suppressive activity against a panel of histologically diverse cancer cell lines.

引用

页码：1253 / 1257

页数：5

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