Rolloamides A and B, Cytotoxic Cyclic Heptapeptides Isolated from the Caribbean Marine Sponge Eurypon laughlini

被引：39
|
作者：
Williams, David E. [1 ,2 ]
Yu, Ker [3 ]
Behrisch, Hans W. [5 ]
Van Soest, Rob [4 ]
Andersen, Raymond J. [1 ,2 ]
机构：
[1] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada
[2] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1, Canada
[3] Wyeth Res, Discovery Oncol, Pearl River, NY 10965 USA
[4] Univ Amsterdam, Inst Systemat & Populat Biol, Zool Museum, Dept Coelenterates & Porifera, NL-1090 AT Amsterdam, Netherlands
[5] Ross Univ, Sch Med, Portsmouth, Commonwealth Do, Dominica
来源：
JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 07期
关键词：
PROLINE; OCTAPEPTIDE; PEPTIDES; PORIFERA;
D O I：
10.1021/np900121m
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two cyclic heptapeptides, rolloamides A (1) and B (2), have been isolated from the Dominican marine sponge Eurypon laughlini. The structures of 1 and 2 were elucidated by a combination of spectroscopic analyses and chemical degradation. Rolloamide A (1), which was found to exist as two distinct conformers in C5D5N, exhibits growth suppressive activity against a panel of histologically diverse cancer cell lines.
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收藏
页码：1253 / 1257
页数：5
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