GRANULATION OF EFFERVESCENT INGREDIENTS FOR OPTIMIZATION OF GASTRORETENTIVE PROPERTIES OF FLOATING PROROXAN PROLONGED-RELEASE TABLETS

被引：2
|
作者：
Nifontova, G. O. [1 ,2 ]
Krechetov, S. P. [1 ]
Dolotova, O. V. [1 ]
Buyukli, S. R. [1 ]
Akhmetzyanova, A. R. [3 ]
Krasnyuk, I. I. [2 ]
机构：
[1] Moscow Inst Phys & Technol, Sch Biol & Med Phys, Dolgoprudnyi 141700, Moscow Region, Russia
[2] IM Sechenov First Moscow State Med Univ, Moscow 119991, Russia
[3] Fed Medicobiol Agcy Russian Federat, Farmzashchita Res & Prod Ctr, Chimki 141402, Moscow Region, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 04期
关键词：
hydrophilic matrix; proroxan; prolonged release; gastroretentive properties; wet granulation; DELIVERY-SYSTEMS;
D O I：
10.1007/s11094-018-1822-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Research results supporting the manufacturing technology for floating prolonged-release oral tablets based on a hydrophilic matrix with the nonselective alpha-adrenoblocker proroxan are presented. Wet granulation of the effervescent ingredients with the matrix produced tablets with the required buoyancy lag-time, float time, and proroxan release kinetics.
引用
收藏
页码：361 / 365
页数：5
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