Pyridazine N-Oxides as Precursors of Metallocarbenes: Rhodium-Catalyzed Transannulation with Pyrroles

被引:33
|
作者
Kanchupalli, Vinaykumar [1 ]
Joseph, Desna [1 ]
Katukojvala, Sreenivas [1 ]
机构
[1] Indian Inst Sci Educ & Res, Dept Chem, Bhopal 462066, Madhya Pradesh, India
关键词
ENALCARBENOIDS DIRECT SYNTHESIS; TERMINAL ALKYNES; DENITROGENATIVE ANNULATION; MULTICOMPONENT REACTIONS; SATURATED HETEROCYCLES; EFFICIENT SYNTHESIS; AZAVINYL CARBENES; FACILE SYNTHESIS; INDOLES; FUNCTIONALIZATION;
D O I
10.1021/acs.orglett.5b03064
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Pyridazine N-oxides are used for the first time as precursors of metallocarbenes. These nitrogen-rich heterocycles led to the discovery of a novel acceptor and donor-acceptor enalcarbenoids. The synthetic utility of these metallocarbenes was demonstrated in the rhodium-catalyzed denitrogenative transannulation of pyridazine N-oxides with pyrroles to the valuable alkyl, 7-aryl, and 7-styryl indoles. The transannulation strategy was applied to the synthesis of a potent anticancer agent.
引用
收藏
页码:5878 / 5881
页数:4
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