Oxygen-dependent mechanisms underlying the antiischemic effect of verapamil and amlodipine

被引：6
|
作者：
Gatsura, SV [1 ]
机构：
[1] Russian State Med Univ, Moscow 117437, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 137卷 / 01期
关键词：
antiischemic effect; hemoglobin affinity for oxygen; lipid peroxidation; verapamil; amlodipine;
D O I：
10.1023/B:BEBM.0000024382.81356.04
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Verapamil and amlodipine produced a potent antiischemic effect and reduced the area of myocardial infarction in rats. The observed changes were accompanied by inhibition of lipid peroxidation. In contrast to verapamil, amlodipine in a dose of 50 ng/ml in vitro decreased hemoglobin affinity for oxygen. Moreover, amlodipine in a concentration of 2 ng/ml decreased the content of malonic dialdehyde and activity of superoxide dismutase in the blood.
引用
收藏
页码：40 / 42
页数：3
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