Oxygen radicals as messengers in oxygen-dependent gene expression

被引:0
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作者
Kietzmann, T
Fandrey, J
Acker, H
机构
[1] Inst Biochem & Mol Zellbiol, D-37073 Gottingen, Germany
[2] IG1, Inst Physiol, D-45147 Essen, Germany
[3] Max Planck Inst Mol Physiol, D-44227 Dortmund, Germany
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中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Changes in ambient Po-2 need to be sensed to allow long-term adaptation of cellular functions via the regulation of gene activity. The generation of OH . from H2O2 in an iron-dependent perinuclear Fenton reaction for triggering gene expression could be the key event in the O-2 signaling pathway.
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页码:202 / 208
页数:7
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