Hyaluronic Acid Nanoparticles as Nanomedicine for Treatment of Inflammatory Diseases

被引：47

作者：

Rao, N. Vijayakameswara ^{[1
,2
]}

Rho, Jun Gi ^{[3
]}

Um, Wooram ^{[1
]}

EK, Pramod Kumar ^{[1
]}

Nguyen, Van Quy ^{[1
]}

Oh, Byeong Hoon ^{[1
]}

Kim, Wook ^{[3
]}

Park, Jae Hyung ^{[1
,4
]}

机构：

[1] Sungkyunkwan Univ, Sch Chem Engn, Suwon 16419, South Korea

[2] Natl Taiwan Univ Sci & Technol, Dept Chem Engn, Taipei 10617, Taiwan

[3] Ajou Univ, Dept Mol Sci & Technol, Suwon 16499, South Korea

[4] Sungkyunkwan Univ, Dept Biomed Inst Convergence SKKU BICS, Suwon 16419, South Korea

来源：

PHARMACEUTICS | 2020年 / 12卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

hyaluronic acid; drug conjugates; polymeric nanoparticles; tumor-targeting; targeted-therapy; inflammatory diseases; type; 2; diabetes; atherosclerosis; GENOME-WIDE ASSOCIATION; MOLECULAR-WEIGHT; INSULIN-RESISTANCE; ORAL DELIVERY; RECEPTOR CD44; TISSUE-INJURY; IN-VIVO; TUMOR; MACROPHAGES; NANOCARRIERS;

D O I：

10.3390/pharmaceutics12100931

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.

引用

页码：1 / 18

页数：18

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