Organocatalytic Enantioselective Morita-Baylis-Hillman Reaction of Maleimides with Isatins

被引：20

作者：

Chauhan, Pankaj ^{[1
]}

Chimni, Swapandeep Singh ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, UGC Sponsored Ctr Adv Studies Chem, Amritsar 143005, Punjab, India

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2卷 / 07期

关键词：

cinchona alkaloids; maleimides; Morita-Baylis-Hillman reaction; organocatalysis; oxindoles; CATALYTIC ASYMMETRIC-SYNTHESIS; VICINAL QUATERNARY; ALDOL REACTION; CONSTRUCTION; FACILE; 3-HYDROXYOXINDOLE; DERIVATIVES; INDOLES; BEARING; CARBON;

D O I：

10.1002/ajoc.201300093

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective Morita-Baylis-Hillman reaction of maleimides with isatin derivatives has been developed. beta-Isocupreidine catalyzes the formation of enantiomerically enriched 3-substituted 3-hydroxyoxindole derivatives in up to 96% yield and enantioselectivity of over 99% ee can be achieved under mild reaction conditions.

引用

页码：586 / 592

页数：7

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