Morita-Baylis-Hillman reaction of acrylamide with isatin derivatives

被引：21

作者：

Singh, Radhey M. ^{[1
]}

Bharadwaj, Kishor Chandra ^{[1
]}

Tiwari, Dharmendra Kumar ^{[2
]}

机构：

[1] Banaras Hindu Univ, Fac Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

[2] Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500007, Andhra Pradesh, India

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 10卷

关键词：

acrylamide; isatin; ketimine; Morita-Baylis-Hillman; phenol; REMARKABLE RATE ACCELERATION; REACTION FACILE SYNTHESIS; CHIRAL QUATERNARY CARBON; EFFICIENT SYNTHESIS; CONSTRUCTION; AMINATION; ADDUCTS; ALKENES; DESIGN; LACTAM;

D O I：

10.3762/bjoc.10.315

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Morita-Baylis-Hillman reaction of acrylamide, as an activated alkene, has seen little development due to its low reactivity. We have developed the reaction using isatin derivatives with acrylamide, DABCO as a promoter and phenol as an additive in acetonitrile. The corresponding aza version with acrylate and acrylonitrile has also been developed resulting in high product yields.

引用

页码：2975 / 2980

页数：6

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